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Biomedical subjects

A D Morley

Publications and source records attributed to A D Morley.

3 recordsLinked to original sources

A review of sinonasal outcome scoring systems - which is best?

* In patients undergoing endoscopic sinus surgery for chronic rhinosinusitis, there is a lack of a universally accepted system for the evaluation of outcome. * This makes critical comparison between results less meaningful. * To determine the most suitable sinonasal outcome scoring system for use in our own practice, we reviewed the available literature and known systems in existence. * We analysed 15 known disease-specific sinonasal outcome indices with emphasis on reliability, validity and responsiveness. * We concluded by choosing one quality of life outcome tool for our departmental use, the Sinonasal Outcome Test-22, due to its reliability, validity, responsiveness and ease of use. * It has been validated to distinguish between disease-affected patient groups and those without rhinosinusitis, demonstrate a worse score if the condition gets worse and show an appropriateness of items and scales in the questionnaire. This has been demonstrated in 3128 British patients.

Chronic Disease↗

Diamine containing VLA-4 antagonists.

Design and synthesis of a library as potential VLA-4 antagonists has been accomplished, based around a proposed pharmacophoric model. Compounds possessing submicromolar potency were identified and structure-activity relationships were seen across the library. Further derivatisation produced compounds with IC(50)'s <10 nmol for inhibiting the VLA-4 mediated binding of fibronectin to RAMOS cells, providing an ideal starting point for a lead optimisation Programme.

Cell Adhesion↗