A D Mosley | PubMed Health

PubMed2005

A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations.

Referral-based studies indicate that a mutation (G2019S) in exon 41 of the LRRK2 gene might be a common cause of Parkinson disease (PD). The authors sequenced leucine-rich repeat kinase 2 (LRRK2) exons 31, 35, and 41 in 371 consecutively recruited patients with PD and found mutations in six (1.6%) subjects, including two heterozygous for new putative pathogenic variants (R1441H, IVS31 + 3A-->G). These data confirm the important contribution of LRRK2 to PD susceptibility in a clinic-based population.

Aged↗

PubMed1995

String editing analysis of human visual search.

Eye movement (EM) data were recorded for human subjects performing a visual search task in a stereoscopic computer-generated three-dimensional scene. Each experimental run consisted of six presentations: three different object placements on a common background (quasi-natural scene) were used and one of the placements was repeated three additional times. Raw EM searchpath data were linearized, fixation points were defined via a fixation algorithm and, finally, strings of fixation region labels were obtained based upon a priori regionalization schemes. Use of string editing techniques allowed quantitative comparison of the similarity of various searchpaths. Analysis of the similarity of searchpaths for each subject, as well as across subjects, led us to conclude that presentation of repeated object placements caused each subject to develop a partly self-consistent, but idiosyncratic searchpath based upon a spatial model for that placement pattern.

Algorithms↗