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Biomedical subjects

A D Pedersen

Publications and source records attributed to A D Pedersen.

2 recordsLinked to original sources

Emergency cricothyroidotomy.

The effectiveness and safety of cricothyroidotomy was reviewed at our institution and in the literature. The literature review yielded nine reports on emergent cricothyroidotomy. Out of 320 patients, there were 308 successful airways and 99 survivors. In 172 cases (eight reports), the patient was not in cardiac arrest, and this group accounted for 84 of 99 survivors. Acute complications were rare and included bleeding and misplacement of the airway. Long-term complications were difficult to evaluate because of the small number of survivors, many of whom were in a permanent vegetative state. At our institution, we had 65 patients who underwent emergent cricothyroidotomy with 62 successful airways and 27 survivors. In 33 patients, vital signs were present at the time of emergent cricothyroidotomy. This group accounted for 25 of 27 survivors. Acute complications were: misplacement or failure to obtain an airway (seven), no airway (three), chest tube required (two), and bleeding (one). In the 27 survivors long-term complications were: failure to decannulate (two), and vocal cord paralysis, granulation tissue and hoarseness, one case each. We conclude that emergent cricothyroidotomy is effective in establishing airways in emergency situations, although the survival rate is better if the patient is not in cardiac arrest (49 vs 31% in literature and 41 vs 76% in our study).

Adolescent↗

Inner ear basic fibroblast growth factor in CBA/J, C3H/HeJ, and autoimmune Palmerston north mice.

Basic fibroblast growth factor (bFGF) has a mitogenic effect on fibroblasts and osteoblasts for matrix proliferation and on endothelial cells for neovascularization. Because otic capsule osteogenesis in autoimmune disease subjects often involves abnormal matrix and vascular changes, bFGF may serve as a potential mediator for such bone disorders. To investigate this relationship, bFGF was evaluated in the Palmerston North autoimmune strain mouse, which develops otic capsule sclerotic lesions during the progression of its systemic disease. Inner ears from PN mice, along with control CBA/J and C3H/HeJ mice, were immunohistochemically stained with antibodies against bFGF to identify its presence and possible role in otic capsule disease. Although cells reactive for bFGF were observed along the lining of the otic capsule in all three strains, a significantly higher frequency was observed in the PN mice. Other sites of staining included connective tissue around the tensor tympani muscle and the geniculate ganglion. This identification of bFGF in the otic capsule raises the possibility that it may play some role in normal bone maintenance, as well as abnormal bone or connective tissue remodeling in autoimmune disease.

Animals↗