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Biomedical subjects

A D Spanta

Publications and source records attributed to A D Spanta.

27 records · Page 2Linked to original sources
PubMed1990

Skeletal muscle ventricles for total heart replacement.

Skeletal muscle ventricles (SMV) were constructed from canine left latissimus dorsi muscle. The animals were divided into three groups: group A (n = 5), SMVs rested 4 weeks without electrical conditioning; group B (n = 6), SMVs rested 4 weeks and then electrically conditioned for 6 weeks; group C (n = 5), SMVs rested 18 weeks without electrical conditioning. At the end of each protocol, the SMVs were acutely tested by connecting them to a mock-circulation device. The SMVs in group C developed stroke work at physiologic preloads superior to any previously reported, as high as 194% of left ventricular stroke work at afterloads of 80 mmHg. The SMVs in group B developed work outputs equivalent to 53% of the left ventricle, which is still more than four times that of the right ventricle. The results show that it is possible to harvest sufficient work from skeletal muscle ventricles to fully replace cardiac function at physiologic preloads.

Adaptation, Physiological↗
PubMed1990

Skeletal muscle ventricles in circulation as aortic diastolic counterpulsators: twelve-month update.

In previous studies, we have shown that canine skeletal muscle ventricles (SMVs) of various designs could develop stroke work intermediate between that of the canine left and right ventricle. We have subsequently reported that SMVs could be used as aortic diastolic counterpulsators. In some animals the SMVs pumped blood effectively for several weeks. Thromboembolism, however, caused renal failure, which was responsible for the demise of the longest surviving animals. More recently, we have studied a group of 15 dogs that had skeletal muscle ventricles constructed from their latissimus dorsi muscle and lined with autogenously derived tissues, either pleura, pericardium or fibrous tissue induced by a Teflon mandrel. We now report on one of those animals, that has survived more than 1 year. She remains active and in apparent good health with no clinical evidence of thromboemboli. Her SMV continues to generate effective aortic diastolic counterpulsation.

Animals↗
PubMed1977

[Human celosomias].

Definition and nomenclature of celosomia are based on a historical review which provides a system of classification. Morphology and organogenesis of celosomia were studied on 64 embryonic and foetal bodies. The anatomical study of 6 cases of human celosomia provided a definition of the characteristics of major celosomia, by showing the constant elements of the syndrome (particularly the parietal malformation) and the anomalies frequently found in each of the different types:--anterior (or superior) celosomia;--middle celosomia, including laparoschisis;--posterior (or inferior) celosomia, among which exstrophy of the bladder may be either one of the constant elements of the syndrome, or a limited form of the inferior celosomia;--total celosomia, of which one case was studied for this report, and of which the major forms, the schistosomia, chelinosomia and strophosomia types, seem to constitute forms of transition with other types of monstruosity. With improved knowledge of anatomy and organogenesis the possibilities of treatment have improved over the past few years, but still remain limited in the more monstrous forms of celosomia.

Abdomen↗
PubMedDate not supplied

Percutaneous discectomy using the electromagnetic field focusing probe. A feasibility study.

The EFF probe has the capability of sharply focusing the eddy currents produced in tissue secondary to the electromagnetic field it generates. This sharp convergence of eddy current produces intense heat at the point of contact of the probe to the tissue, which can vaporize tissue. The probe diameter can be as small as required which makes it easy to be navigated into disc space for disc vaporization. Four discs were vaporized in three pigs by inserting the probe into the disc and vaporizing it. The vertebral columns were removed and transverse sections through the disc were made. Excellent disc vaporization was observed with vaporization of 70-80% of the nucleus. As the probe can be of flexible material it could be turned in different directions to vaporize necessary disc material.

Animals↗