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Biomedical subjects

A D Vorob'eva

Publications and source records attributed to A D Vorob'eva.

15 recordsLinked to original sources

[The morphometric characteristics of the neurons of the reticular nuclei in the brain stem in the kitten].

In the brain stem of 30-day-old kittens three types of Golgi-stained neurons are distinguished: sparsely branched reticular neurons, densely branched arborescent neurons and multipolar giant neurons (according to the classification by Leontovich). Implication of the new method of computer morphometry permits obtaining formalized characteristics of 23 parameters of the above types of neurons. An analysis of the quantitative characteristics of the studied neurons has revealed statistically significant differences in most parameters. This fact permits advancing a conclusion about morphological identity (stability) of each type of the neurons. Structural differences and similarities in reticular nuclei are discussed with respect to their functional features.

Animals↗

[The effect of sectioning the lingual nerve on the morphometric characteristics of the reticular nuclei in the brain stem in the kitten].

Three subpopulations of Golgi-stained neurons of the brainstem reticular nuclei have been studied by the method of computer morphometry in 30-day old kittens. 23 parameter of the neuronal geometry were analyzed after uni-and bilateral lingual nerve section 5-7 days after birth. All of cells display statistically valid changes in some parameters, typically differing in every group: for reticular neurons--free distribution of dendrite endings in the dendritic field; for arborescent ones--the length of dendritic segments; for giant multipolar neurons--distribution of foci of maximal dendrite branching in the dendritic field. Unilateral lingual nerve section gives more pronounced quantitative deviations from the normal state, than bilateral one.

Animals↗

[Dendrite orientation in neurons of the reticular brain stem nuclei of a kitten after oral deafferentation].

Deviations in orientation of dendrites in neurons of the reticular brainstem nuclei are demonstrated in the Golgi preparations of the brain of 30-day old kittens by means of the computerized morphometry. Changes in the density of dendrite orientation occurring after bilateral and unilateral lingual nerve section are considered with respect to the following afferent inputs: midline structures and trigeminal and vestibular nuclei.

Afferent Pathways↗

[Comparative concentration of serum free amino acids in patients with incipient and manifest organic neuropsychiatric disorders of vascular origin].

The authors conducted a study of the quantitative content of amino acids in the blood serum of patients with initial and expressed organic neuro-psychic disorders of a vascular genesis and in a group of normals of the same age. In patients with initial organic syndromes the content of cystin-cystein and treonine in the blood serum increased. In patients with expressed organic syndromes the content of cystin-cystein increased, while the content of arginine acid and leicyn-isoleicyn decreased as compared to the control group of elderly people. A comparative study of the two groups of patients with organic psychopathology of a vascular origin demonstrated that in vascular dementia there are more severe changes in the content of amino acids in the blood serum.

Aged↗

[The quantitative morphological characteristics of the neurons of the anterior horns of the spinal cord in the kitten].

Golgi preparations of cervical part of the spinal cord of 30-day kittens were used to study sparely and densely branching neurons of lamina VII, sparely and densely branching neurons of lamina VIII and big densely branching motor neurons (as classified by Leontovich) of medial and lateral regions of lamina IX. Qualitative morphological characteristics of geometry of each cell type were obtained by the method of computerized morphometry. The details of the structure of neurons belonging to different laminae of grey matter are discussed.

Animals↗

[The quantitative morphological characteristics of the spinal neurons in the kitten developing under conditions of limited afferent input].

Golgi preparations of cervical part of the spinal cord were used to study sparely and densely branching neurons of lamina VII, sparely and densely branching neurons of lamina VIII and large densely branching motor neurons of lamina IX in 30-day kittens developing under the conditions of limited reticulospinal input. Limitation was induced by electrocoagulation of bulbar magnocellular nucleus and caudal reticular pontine nucleus performed at the 7th day. Computerized morphometry revealed that partial deafferentation affects the geometry in all studied cell types except densely branching neurons of lamina VIII. Adaptive nature of structural reorganization of spinal neurons and possible relationship between morphological properties and functional profile of cells are discussed.

Animals↗

[The advanced display of behavioral reactions in sensory deprived rat pups].

Bilateral section of nervus medianus was made in Wistar rat pups on 13, 14, 15 or 16-th days of life. Developmental analysis of motor abilities, locomotor and exploration activities during 10-30 days of life revealed three groups of facts. 1. Partial deafferentation of forelimbs don't influence on some types of behavior. 2. Some motor abilities hindered in rat pups with section of nervus medianus. 3. Partial deafferentation of forelimb gives rise to the faster appearance of the new types of behavior. The developmental analysis allowed to suggest that faster appearance of certain behavior reactions after deafferentation of the forelimbs is a result of actualization of latent sensory inputs including in the organization of these types of behavior but it is not connected with changing of velocity of morphological maturation.

Aging↗

[Sensory information--an important factor in ontogeny].

Ontogenetic process reveals a row of consecutive stages characterized by the gradual increase in complexity and by the changing specificity of sensory mechanisms basic for the adaptive behavior of the young. The study examines the mechanisms of interaction among different sensory systems during the formation of early behavioral patterns and analyzes why, at a certain stage of development, a particular sensory stimulus loses its efficacy in the organization of a given behavior and is substituted by another one, previously ineffective. A special attention is paid to formation of behavior based on sensory information within the limits of ontogenetically fixed developmental critical periods and to the role of the early sensory experience in learning in adult animals.

Aging↗