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Biomedical subjects

A D Weaver

Publications and source records attributed to A D Weaver.

At least 19 recordsLinked to original sources

Cutaneous melanocytomas in 10 young cattle.

Ten melanocytomas from 10 cattle were diagnosed by histopathologic examination of biopsy specimens submitted to the Veterinary Medical Diagnostic Laboratory, University of Missouri, between 1 January 1986 and 31 December 1993. One tumor was congenital; the others were first noticed between 2 months and 2 years of age (means = 9.9 months). Six tumors occurred in purebred (3) or crossbred (3) Angus cattle; one tumor each occurred in a Holstein, a Shorthorn, a Simmental, and a beef calf of unrecorded breed or coat color. Five calves were female, and five were male. Five tumors occurred in truncal dermis or subcutis (three in abdominal skin), four occurred on a limb, and one occurred on the jaw. Tumors varied in histologic appearance, but all were pigmented and all had few mitotic figures. Outcome was known for 8/10 cattle. In four cattle followed for at least 1 year, the tumor did not recur after surgical excision. Another heifer had residual gray tissue at the tumor site after surgery but remained in the herd without regrowth of the tumor 30 months after excision. Three other calves were slaughtered within 6 months of excision without apparent recurrence of the tumor.

Animals

Duodenal perforation and abdominal abscess in a cow.

A mature Jersey cow developed duodenal perforation and localized abscessation. After failure of a right flank marsupialization procedure, a side-to-side duodenojejunal anastomosis was created. The duodenum distal to the anastomosis was ligated and the original duodenal fistula was closed with chromic gut sutures. The abscess cavity was sutured to the right lateral body wall for drainage, and the cow recovered slowly.

Abdominal Muscles

Fatal transesophageal carotid arterial perforation by thorns in a calf.

A Charolais bull calf died about 4 days after perforation of the left common carotid artery by thorns of a twig that had become lodged temporarily in the esophagus. The calf initially drooled blood-tinged saliva and drank with difficulty. Necropsy revealed severe anemia and a large volume of blood in the gastrointestinal tract.

Animals

Survey with follow-up of 67 dogs with testicular sertoli cell tumours.

Sixty-seven cases of canine sertoli cell tumour are reviewed. The mean age at diagnosis was 9.5 years (sd +/- 2.1, range 3 to 17). The most commonly affected breeds were boxer, cairn terrier, labrador retriever, border collie, German shepherd and rough collie. The left side was affected in 28 dogs (42 per cent), the right in 35 (52.5 per cent) and both sides in four (6 per cent). Twenty testicles were abdominal (left, seven; right, 13), seven were inguinal (left, four; right, three) and 44 were scrotal (left, 21; right, 23). Hormonal signs were evident in 38 (57 per cent) animals (feminisation with alopecia in 21, symmetrical alopecia alone in 17). Other types of testicular tumours were found in 12 dogs (18 per cent) of this series. Of 42 dogs which were castrated and discharged, 38 were available for follow-up study and survived for between one week and five years. Two of the 15 dogs which were subject to post mortem examination had metastases. Two others which died after failure of remission, or a recurrence of the hormonal changes probably also had metastases. Two of the 25 dogs which were presented initially for other reasons, but had sertoli cell tumours, were found to have metastases post mortem. The boxer, cairn terrier, border collie, Shetland collie and pekingese had a higher risk of sertoli cell tumour than other breeds.

Animals

Survey of lameness in British dairy cattle.

During 1977 a survey was undertaken by practising veterinary surgeons of the incidence of different lesions causing lameness in dairy cattle. Forty-eight veterinary practices participated and they treated 7526 cases of lameness in 1821 herds. The average incidence of lameness among all cows was 5.5 per cent and the annual incidence among practices ranged from 1.8 to 11.8 per cent. Most lesions (88.3 per cent) occurred in the feet; the commonest were foul of the foot (16.7 per cent), white line abscess (15.6 per cent), sole ulcer (13.6 per cent), punctured sole and pus (10.4 per cent) and underrun heel (8.7 per cent). These proportions varied in different parts of the country. Eighty-four per cent of foot lesions occurred in the hind feet and of these lesions 85 per cent occurred in the outer claw; 42 per cent of foot lesions occurred in abnormally shaped claws. The remaining 11.7 per cent of lesions occurred in the legs and trunk, 76 per cent of which occurred in the hindlimb. Trauma was the main cause of leg lesions, which occurred most frequently in the joints and ligaments.

Animals

Visits to European veterinary schools by United Kingdom veterinary school staff.

In 1979 a questionnaire was sent to 355 academic staff of the six United Kingdom veterinary schools concerning visits to European veterinary schools, as information was sought by the Royal College of Veterinary Surgeons on staff mobility. Two hundred and thirty seven (67 per cent) replied. Within the previous five years, 32 per cent of 236 staff had made at least one such visit. A further 15 per cent had visited a school more than five years previously, while 53 per cent had made no visit. The sources of finance were extra-university funds (38 per cent of the visits), home university (28 per cent), host university (15 per cent) and personal funds (18 per cent). The British Council was the most frequent outside source. The reasons given by staff for not having visited a school in the last five years were lack of funds (65 per cent of non-visitors), lack of contacts (48 per cent) and lack of time (47 per cent). Inability to speak a foreign language (27 per cent), lack of interest (8 per cent) and other reasons (14 per cent) were also cited. Twenty nine different schools had been visited by 73 individuals in the last five years, Hanover and Utrecht most frequently. Language fluency of the staff was generally poor. There was overwhelming support for the improvement of the facilities and arrangements for study and teaching visits to veterinary schools in European countries.

Europe

Massive scrotal swelling in two unusual cases of canine sertoli-cell tumour.

Two cases of Sertoli-cell tumour in dogs in which the presenting sign was a partially reducible scrotal swelling are described. In one animal intravenous extension of the tumour had led to varicosity of the testicular vein while lymphatic extension had resulted in the formation of both sublumbar and intrathoracic growths. In the second animal there was massive hydrocoele and some varicosity of the distal testicular vein and there was again lymphatic spread with tumours in the sublumbar lymph nodes and the spleen. Both animals showed changes considered to be evidence of feminisation.

Animals

Comparison of standard chelating agents for acute mercuric chloride poisoning in mice.

A comparison in mice has been made of the effectiveness of five chelating agents used clinically for acute mercuric chloride poisoning, or recommended for such use. The compounds examined were N-Acetyl-D,L-penicillamine (NAPA), D-penicillamine (DPA), 2,3-dimercaptosuccinic acid (DMSA), sodium 2,3-dimercaptopropanesulfonate (DMPS), and 2,3-dimercaptopropanol-1 (BAL). The test of effectiveness was their ability to reduce the mortality of acute mercuric chloride poisoning when administered 20 minutes after the mercury at chelate:mercury mole ratios of 10, 15, 20, and 30. All except BAL were found to be effective at the highest mole ratio tested, but N-Acetyl-D,L-penicillamine and sodium 2,3-dimercaptopropanesulfonate were significantly more effective than DMSA and BAL at mole ratios of 10:1. The relative effectiveness does not correlate with available data on stability constants. The toxicity of BAL itself becomes apparent at mole ratios of 20:1 and above.

Animals

Extramural study experience and practical experience of final year veterinary students of nine European schools.

Arrangements for extramural education including "seeing practice" experience in nine European veterinary schools (Bristol, Glasgow, Liverpool, Helsinki, Stockholm, Hannover, Ghent, Toulouse and Vienna) are described. Considerable differences existed between three UK schools, and between them and the Continental schools, where arrangements were usually voluntary. The amount of extramural experience in different types of work was quantified by student questionnaires. An average of 12 weeks' experience in farm practice was gained by 83 per cent of the 339 students, six weeks' small animal work by 48 per cent, four weeks in an abattoir by 43 per cent and other periods in specialised practices, laboratories and veterinary faculties. Practice abroad was experienced by 10 per cent. The total experience of different medical and surgical conditions varied considerably between schools as a result of disease eradication (eg, swine fever in UK), non-occurrence (canine leptospirosis in Sweden and Finland) or the availability of surgical or reproductive material, as well as on other factors.

Curriculum