PubMed Health⌕ Search

Biomedical subjects

A Düx

Publications and source records attributed to A Düx.

At least 19 recordsLinked to original sources
PubMed1994

Disseminated growth of Hodgkin's-derived cell lines L540 and L540cy in immune-deficient SCID mice.

Local tumor growth has been reported after subcutaneous and intraperitoneal injection of Hodgkin's disease (HD) derived cell lines into different immunodeficient mouse strains. An animal model with disseminated growth of tumor cells would be useful for studying the in vivo biology of HD cells as well as for preclinical testing of new therapeutic regimens. For this purpose the HD-derived cell lines L540, L540cy, L428, and KM-H2 were injected intravenously into SCID mice. In contrast to L428 and KM-H2, widespread neoplasia occurred after a period of four to six weeks following injection of L540 and the subline L540cy. Lymph nodes were found to be the preferred site of tumor growth. CD30 surface antigen expression on Hodgkin cells and the karyotype of the tumor cells were preserved in the animal host. Thus, to a large extent, the SCID mouse model mimics the dissemination pattern of Hodgkin's disease in man. To evaluate the role of adhesion molecule expression in the dissemination of HD-derived cell lines, CD44 and members of the immunoglobulin, integrin, selectin, and Fc receptor families were quantified by flow cytometry. CD30 expression was also measured. Although CD44 expression has been correlated with dissemination in non-Hodgkin's lymphoma (NHL), this was not the case in the Hodgkin's SCID mouse model. CD44 was not expressed on the disseminating cell lines L540 and L540cy but was expressed in the nondisseminating lines L428 and KM-H2.

Animals↗
PubMed1989

[Arteriovenous fistula of the kidney--angiography case descriptions].

Individual case reports serve to demonstrate the pathogenetically different renal arteriovenous shunt formations, such as congenital arteriovenous angioma, spontaneous arteriovenous aneurysm, iatrogenic arterio-venous fistula and neoplasia-conditioned arteriovenous fistula. These are discussed in detail, including treatment possibilities. The ranking of digital subtraction angiography is emphasised. Our case reports show that in preoperative diagnosis of pathological structures in the kidney, renovasography is an invaluable tool, especially with i.a. DSA technique, and is superior to all other methods such as sonography, CT, MR and colour-coded Doppler sonography. Due to improved techniques of angiography (markedly lower amounts of contrast medium when using catheters of narrow lumen) indication for i.a. DSA in haematuria of unknown origin should be liberal. Above all, the method should be performed at an early stage. If there is a NAD renal finding in the i.a. DSA renovasogram in renally conditioned haematuria even when using a 1024 x 1024 image matrix, it is advisable to perform selective renal arteriography to either exclude or confirm the existence of an intrarenal angioma, additionally in conventional sheet film technique because of the superior power of resolution.

Adolescent↗
PubMed1988

[The "hepatoceliac collateral" in complete hepatomesenteric trunk--a first angiography observation].

In the example presented here we determined a complex anomaly of the large arterial vessels of the upper abdomen in combination with an intrahepatic vascular malformation (partially thrombosed haemangioma), this identification having become possible by superselective arteriography. There were two anastomoses of considerable calibre besides a complete truncus hepatomesentericus. We named one of these "hepato-coeliacal collateral". This collateral is now being described for the first time in literature and is demonstrated via angiography. Taking into account the embryogenesis of the visceral arteries and the organogenesis of the upper abdominal organs, we offer an interpretation of the development possibilities of the "hepato-coeliacal collateral".

Adult↗
PubMed1987

Low dose intraarterial cis-platinum/radiotherapy after local tumour preradiation.

The simultaneous use of intraarterial Cis-Platinum and Radiotherapy (CP/RT) was found to be a very effective and relatively little burdened treatment for a palliative treatment concept. This affects life quality as well as the remission--and survival times. The fast and continual remission with low CP/RT concentrations, even in extreme palliative cases, is surprising. CP/RT treatment shows additive and synergistic effects which are not explainable by the single effects of the cis-platinum dose used (60 mg/1.73 m2 in our case) or the total irradiation dose (e.g., 5 Gy TD) or the fractionation (e.g., 5 X 1 Gy), especially since the doses of each which were used are by themselves without therapeutic relevance. Only the combination of the modalities with a low dose two-day preradiation program induced the described effects.

Cisplatin↗
PubMed1982

[Embolization of the splenic artery. Emergency therapy in varices hemorrhage and in hypersplenism].

In bleeding of oesophageal varices with resistance to common treatment embolisation of the splenic artery causes depression of the portal hypertension by forty per cent. Thrombosis of the splenic or portal vein as in splenectomies are not to be expected. The splenic vein remains open for later spleno-renal anastomosis. By occlusion of the splenic artery we were successful in stopping oesophageal bleeding. In a patient with dominant hypersplenism in portal hypertension the severity of the syndrome decreased after embolisation of the splenic artery. Thrombocytes, leukocytes and gammaglobulin increased.

Embolization, Therapeutic↗
PubMed1982

[Herniations and prolapses of the diaphragm (author's transl)].

Diseases and changes of the diaphragmal region should be investigated radiologically. Computed tomography will give additional information. Special attention should be paid to patients after traumatic injuries of breast and body. 95% of which are sliding gastro-esophageal herniations.

Accidents, Traffic↗
PubMed1979

[Radiological diagnosis of the ösophagus with special attention to the ösophagogastric transition of the gastro-ösophageal reflux, reflux ösophagitis, hiatal hernias and ösophageal stenoses (author's transl)].

The inferior high-pressure zone acts like a functional sphincter. This is formed in the absence of a muscle correlate, via a regional predominance of the sphincter tone caused by inhibition of activity of the longitudinal muscles through the membrane phreno-oesophagea in the region of the vestibulum gastro-oesophageale. Pressure variations in the vestibulum caused by respiration, are governed by a "rein mechanism". Swallowing produces a brief reflectory breakdown of the inferior high-pressure zone in the longitudinal muscles of the ösophagus via myogenic ventricular stimulus condution. Gastro-ösophageal reflux can be regularly identified by means of suitable x-ray examination technique. Since, however, it is not possible to arrive at a quantitative and qualitative assessment of the reflux via roentgenology, the aim of radiological examination in case of clinical suspicion of reflux is to determine a) the factors favouring reflux, ie hiatal hernia, gastric and duodenal ulcer, stenosis of the pylorus, etc, b) the sequelae of a pathological reflux, eg reflux stenosis, reflux ulcer, brachyösophagus etc, as well as c) to assess the self-cleaning function of the ösophagus. It is possible to definitely identify hiatal hernia by radiology with a well-aimed examination technique, through the intrathoracal displacement of parts of the stomach, of Schatzki's ring, and the superhiatal displacement of the entire vestibulum gastro-oesophageale. It is also regularly possible to identify by serial radiography an organic ösophagus stenosis, using large quantities of barium swallow, although pathogenetic interpretation of the x-ray film may be difficulat. Functional stenosis can be defined by pharmacoradiography and manometry. In clinically suspected reflux ösophagitis, endoscopy and histology will supply more conclusive findings in respect of mucosal assessment than x-ray examination.

Aged↗
PubMed1976

[Superior and inferior cavography as well as azygography and retroperitoneal venography: methods, indications and results (author's transl)].

The diagnostic spectrum for venography of the trunk is broad. During the traditional superior and inferior cavography, which should be used for clinical bone marrow functional blockage in connection with a confirmed tumor or for thrombosis, the combined retroperitoneal venography and cavography which we developed for clinical use as well as direct azygography provide valuable supplementary information which can be significant especially for preoperative questions. In the case of carcinoma of the esophagus or stomach, the question whether or not the tumor can be surgically removed or whether the tumor is already inoperable may be answered before surgery. In addition, direct azygography is suitable as a method to seach for lymph nodes metastases in carcinomas of the lung, stomach, kidney, adrenals and pancreas which cannot be ascertained via mediastinalscopy, and for systemic diseases. In addition to the prognostic evaluation of the tumor and the additional preoperative evaluation of neighboring tumors, various bone diseases of the lumbar vertebrae, e.g., inflammatory, tumerous and traumatic changes in the spine, may be localized on the retroperitoneal venogram and cavogram. They can also be used successfully to seach for metastases or in the case of a dislocation of an intervertebral disk. The execution of the various methods is relatively simple and they may be performed on a patient capable of surgery.

Adult↗