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Biomedical subjects

A Daggett

Publications and source records attributed to A Daggett.

10 recordsLinked to original sources
PubMed1996

Hysteroscopic endocervical resection.

A new method was developed to access the uterine cavity in women in whom cervical stenosis precludes hysteroscopic surgery. Thirty-three women with intractable uterine bleeding were chosen to undergo either hysteroscopic myometrial resection or myomectomy. All of them had cervical stenosis that would, in the authors' opinion, not permit safe dilatation to 9 mm, the minimum diameter necessary to introduce a gynecologic resectoscope. Endocervical resection was performed in all 33 patients, with safe, easy access to the uterine cavity. No cases of fluid overload or excess bleeding occurred. We conclude that hysteroscopic endocervical resection is a safe method to create a portal of entry to the uterine cavity in women with absolute or relative cervical stenosis.

Cervix Uteri↗
PubMed1994

Hysteroscopic endomyometrial resection: a new technique for the treatment of menorrhagia.

Thirty-five patients with menorrhagia and a normal uterine cavity underwent hysteroscopic endomyometrial resection. None underwent any form of medical or surgical preparation of the endometrium. A standard gynecologic resectoscope was used to excise a minimum of 3 mm of endomyometrium from the entire uterine cavity. This depth was reduced to 2 mm at the tubal ostia. All patients were followed for 3-6 months. Twenty-one of the 25 patients (84%) who were followed at 6 months reported amenorrhea. The mean dysmenorrhea scores improved from 2.84 to 0.56 postoperatively. Seven of the 35 patients were diagnosed with adenomyosis. One woman was found to have adenomatous hyperplasia of the endometrium. Hysteroscopic endomyometrial resection is a highly effective method for the treatment of menorrhagia. This technique produces a very high rate of amenorrhea, provides a histologic specimen of the endomyometrium, and obviates the need for medical or surgical preparation of the endometrium.

Adult↗
PubMed1993

Hysteroscopic management of intractable uterine bleeding. A review of 103 cases.

One hundred three patients with intractable uterine bleeding were treated using the continuous flow resectoscope. All patients underwent diagnostic hysteroscopy and endometrial sampling prior to surgery. The patients were divided into three groups. Group I (n = 69) patients had a normal hysteroscopic examination. Group II (n = 26) had intrauterine pathology visible on their diagnostic hysteroscopy. Group III (n = 8) had failed to improve satisfactorily on previous hysteroscopic ablation of the endometrium using the Nd:YAG laser. Group I and III patients underwent hysteroscopic ablation of the endometrium using a 3-mm, ball-end electrode. Group II patients underwent hysteroscopic resection of an intra-uterine lesion utilizing a 7-mm wipe loop electrode. The results in all three groups were analyzed and compared. Seventy patients underwent endometrial preparation with one of five pretreatment regimens: danazol, depoleuprolide, depomedroxyprogesterone acetate and surgery.

Adult↗
PubMed1984

Maximum oxygen uptake utilising different treadmill protocols.

The study compared five treadmill protocols (four utilising a motorised, and one a non-motorised, treadmill) on maximum oxygen uptake. The five male and five female subjects, all actively engaged in training, were assigned the tests in random order. Statistical analysis revealed no significant differences between the five protocols for maximal oxygen uptake, maximum ventilation, maximum heart rate and blood lactate inflection point, relative to maximal oxygen uptake. Significant differences were observed between the 3' protocol with incline increments of 1.5% and all other protocols on time to exhaustion (p = less than 0.01) and maximum blood lactate levels (HLA, p = less than 0.05). The results indicate that the protocols used in this study did not significantly influence the maximum oxygen uptake attained.

Exercise Test↗
PubMed1984

Physiological changes and sleep responses during and following a world record continuous walking record.

Physiological changes, and subsequent sleep responses, were recorded in a male subject during and following 338 miles of continuous walking and consequent sleep deprivation. One hundred and thirty hours of walking and a seventy-two hours post-walk recovery period were monitored. The subject walked at approximately 55% of maximum oxygen uptake (VO2 max), heart rate ranged between 102-106 b/min, and blood lactate (LA) remained below the 2 mmol/l level. No electrocardiograph abnormalities were observed either during the walk or pre- and post-functional diagnostic graded exercise test (FDGXT). Creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) levels rose throughout the walk but exhibited differing depletion patterns. The ratio of CK-MB to CK (MB/CK%) did not exceed levels which are suggestive of myocardial ischaemia. Haematological variables demonstrated signs of anaemia towards the end of the walk. Catecholamine levels rose throughout the walk, with greater rises being observed in nor-adrenaline and dopamine. During the post-walk recovery phase, adrenaline concentration remained elevated. Following this extreme period of exertion, the subject demonstrated very short sleep latency and rapid entry into slow wave sleep (SWS). These sleep patterns were compared to sleep recordings made over a similar period (72 h) six months post-walk, when the subject was not exercising. Nocturnal growth hormone (GH) levels were significantly raised on the post-walk nights.

Anemia↗
PubMed1983

Serum creatine kinase and creatine kinase MB isoenzyme responses of post-infarction patients after a graded exercise test.

The response of total creatine kinase (CK) and the creatine kinase isoenzyme (CK MB) was studied in 22 male post-infarction patients (three to six months after myocardial infarction) after a functional graded exercise test, before entering a rehabilitation programme. Eleven subjects (group A) completed the test without developing significant electrocardiographic abnormalities. Eleven subjects (group B) showed changes that necessitated premature termination of the test. No significant differences were observed before the functional graded exercise test between the groups in serum concentration of CK, CK MB, and the percentage of CK MB to CK (MB/ CK%). The two groups were significantly different (p less than 0.01) 24 hours after the graded exercise test in CK MB and MB/CK%, but not in CK. In group B, CK and CK MB rose significantly after the graded exercise test (p less than 0.05) as did MB/CK% (p less than 0.01). In group A only CK showed a significant rise (p less than 0.05). It is probable that increases in CK MB after exercise arise from myocardial tissue efflux, reflecting reversible ischaemia. It is concluded from this study that CK MB appears to be a specific indicator of myocardial ischaemia and could, therefore, be of significant assistance in the clinical and functional assessment of the post-infarction patient.

Clinical Enzyme Tests↗
PubMed1982

Serum creatine kinase and isoenzyme responses of veteran class fell runners.

The exercise response of creatine kinase (CK) and creatine kinase MB (CK-MB) was studied in 11 veteran class male fell runners (aged greater than 40 years) following (1) a laboratory functional diagnostic test (GXT) to maximum oxygen uptake (VO2max), (2) a competitive fell race (8 km distance and 419 m total height gain) at approx. 80% VO2max. Subjects rested for 72 h pre- and 24 h post-GXT test, resuming normal training for 8 days before resting again 72 h pre- and 24 h post-fell race. Blood samples were obtained during normal training, pre- and 24 h post-GXT test, and pre-, 24 and 48 h post-fell race. Two distinct exercise profiles emerged. Post-GXT test CK-MB rose significantly (mean 2.0 U x 1(-1), p less than 0.05) with the mean values of per cent CK-MB to CK (MB/CK%) rising to 4.4% (p less than 0.01). Total CK remained stable at 50 U x 1(-1). Post-fell race CK-MB rose significantly (mean 2.4 U x 1(-1), p less than 0.01) with the mean MB/CK% rising to 3.1% (p less than 0.05) and total CK to 81.6 U x 1(-1) (p less than 0.01). Two subjects who exhibited ECG abnormalities during and post-GXT test, were observed to have the highest MB/CK% post-test (8.2 and 5.6% respectively) and the highest CK-MB (2.3 and 3.7 U x 1(-1). An inverse relationship was observed between MB/CK% and time to complete the fell race. It is probably that the increase in serum isoenzyme CK-MB following exercise arises from myocardial tissue efflux, reflecting reversible ischaemia. CK-MB appears to be a very specific indicator of myocardial stress during exercise.

Adult↗
PubMed1977

Responses of adult women to programmed exercise.

A group of eighty healthy women was studied following two months of programmed exercise (3 x 15 mins/per week) at 60 to 80 percent of age-predicted maximum heart rate. Physical work capacity corresponding to a heartrate of 170 bts. (PWC-170) was determined using a bicycle ergometer. Anthropometric and lung function variables were also ascertained prior to (T1) and following training (T2). The post training measurements of this exercise group, compared with measurements of a sedentary control group, displayed significant changes in PWC-170, resting systolic blood pressure and fat index. There were no significant changes in vital capacity, forced expiratory volume in one second (FEV1), strength and perceived exertion measures (RPE). The implication of these findings are discussed.

Adult↗