PubMed Health⌕ Search

Biomedical subjects

A Dal Pozzo

Publications and source records attributed to A Dal Pozzo.

At least 19 recordsLinked to original sources
PubMed2000

Synthesis and anti-aggregatory activity of linear retro-inverso RGD peptides.

Six retro-inverso tri- and tetrapeptide analogues of RGD were prepared and their anti-aggregatory activity was determined by platelet aggregation tests in comparison with the corresponding parent peptides. An efficient method for the introduction of a malonyl-aspartic residue into a peptide chain is described for the first time. A 2-3-fold decrease in potency or total loss of bioactivity was observed with the new peptides; structure-activity relationships are discussed.

Amides↗
PubMed1991

Percutaneous absorption of nicotinic acid derivatives in vitro.

The permeation rates through isolated epidermis of a homologous series of glycol, polyglycol, and alkyl esters of nicotinic acid were measured in vitro in a two-compartment diffusion cell assembly, using an isotonic buffered solution as the receiving phase. The esters were applied from aqueous solutions and also as the pure liquids. The results were consistent with those reported by other using compounds of equal or different structures either in vitro or in vivo. The experiments are compared in terms of partition equilibrium between vehicle and tissue and distribution from tissue to the receiving phase. It was demonstrated that the plateau observed in skin permeabilities of the compounds beyond a certain degree of lipophilicity is the result of the effect of water when used as the vehicle in the laboratory models.

Chromatography, High Pressure Liquid↗
PubMed1991

[The echo-guided fine-needle biopsy of thoracic and abdominal masses].

Five hundred and seventy-two US-guided fine-needle biopsies were performed on 561 patients (1.2 puncture/patient); in two cases only minor complications were observed. The patients were 12 to 86 years old--most of them ranging 40 to 75. In 5.42% of cases FNAB proved inadequate; 1.75% of the diagnoses was questionable, 28.89% was negative, and 63.98% positive. A comparison with histology was possible in 218 cases: 2 false positives and 5 false negatives were observed. The low rate of false-positive findings demonstrates US-guided FNAB to have high positive predictive value. The method had 95% sensitivity, 98.4% specificity and 84.3% accuracy. The high reliability of FNAB depends on the possibility of centering the lesion through the direct US visualization of the needle tip. This characteristic, together with the presence of the cytologist, who immediately evaluates the aspirated material, helps reduce the number of unnecessary biopsies and, consequently, complications.

Abdomen↗
PubMed1989

[Non-traumatic colic perforation in free peritoneum. Apropos of 61 cases].

Sixty-one non-traumatic perforations in free peritoneum are reported. The principal aetiology is diverticulitis (35 cases) followed by cancer (22 cases). 18 derivations were carried out, 34 colectomies without anastomosis, 5 ideal colectomies and 4 diverticulectomies. Total mortality was 19.7-14% for diverticulitis, 22.2% for perforations at the cancer site, 50% from diastasic perforations. Stress is laid on the need to treat colic perforation by colectomy without anastomosis, confining derivation openeum. Sixty-one cases.

Adult↗
PubMed1988

[Thin-needle aspiration cytology of palpable lymph nodes. Analysis of 702 consecutive cases].

Seven-hundred-two needle aspirates were taken from palpable lymph nodes between january 1982 and june 1987. Cytohistological correlation in about 70% of the preparations showed that the technique is capable of detecting neoplastic cells in 99% of metastases and in 90% of lymphoma cases. Certain technical aspects of smear preparation are pointed out with a view to reducing the percentage of inadequate samples (14% in the present series) and the position of the technique among other diagnostic procedures is discussed, with evaluation of advantages and limitations.

Biopsy, Needle↗
PubMed1988

[Intra-abdominal rupture of varices of the round ligament: a rare cause of hemoperitoneum in patients with cirrhosis].

The authors report two cases of haemoperitoneum due to intra-abdominal rupture of the round ligament in cirrhotic patients with portal hypertension. A review of the literature on the subject reveals the rarity of such observations. The eventuality must be borne in mind, however, in the treatment of the haemorrhagic complications of portal hypertension in view of the associated high mortality. Simple ligature of the bleeding varix is the operation which offers the greatest possibility of survival.

Hemoperitoneum↗
PubMed1987

3-Carbonylacrylic derivatives as potential antimicrobial agents. Correlations between activity and reactivity toward cysteine.

A number of 3-carbonylacrylic acid derivatives were prepared, with a view to varying systematically the stereoelectronic environment of the conjugated double bond. The rates of reaction with cysteine were measured spectrophotometrically when possible or by stopped flow when very fast. Some of the final reaction products were isolated. Other properties examined were partition substituent constants and antimicrobial activity. On the basis of published data and these studies, the activity appears to be the combined effect of at least two mechanisms, one probably related to the effect of these structures on surface tension, the other to the electrophilic properties of the unsaturated system.

Acrylates↗
PubMed1986

Synthesis and antimicrobial properties of new aroyl-acrylic esters of polyethylene glycols.

Eight new aroyl-acrylic esters of polyethylene glycols were prepared using different synthetic ways. They are supposed to possess a higher activity as antimicotic agents for topical use, by favouring skin absorption. Except in few cases, the antimicrobial activity of the oligomeric derivatives resulted generally decreased in vitro, in comparison to simple alkyl esters previously prepared. However, only pharmacological screenings for antimicotic activity in vivo will give a definite response on whether the new derivatives are advantageous for topical use.

Acrylates↗
PubMed1985

[Traumatic chylothorax (apropos of a case following a closed vertebral-thoracic injury)].

The authors report a case of chylothorax due to blunt trauma with fracture of the spine in a man aged 60. After mentioning the possible pathogenesis and clinics of the case shown, the Authors explain the treatment successfully adopted, that is, the ligature of thorax duct at his inlet in the thorax through right thoracotomy on the 5th intercostal space.

Chylothorax↗
PubMed1983

Comparative binding studies of anticonvulsant drugs to bovine serum albumin.

The ability of a new anticonvulsant drug, denzimol, to interact with bovine serum proteins has been studied, in comparison with diphenylhydantoin and carbamazepine. Albumin proved to be the protein fraction responsible for the binding. The association constants were determined in vitro by means of equilibrium dialysis. Additional investigations showed that there was no consistent inhibition by denzimol of the other two drugs binding and vice versa. These data were obtained as a preliminary evaluation of the influence of protein binding in vivo.

Animals↗
PubMed1979

alpha, beta-Unsaturated gamma-lactones correlations between lipophilicity and biological activity.

A homogeneous series of alpha, beta-unsaturated gamma-lactones was prepared. Their in vitro activity against various microorganisms was quantitatively correlated, with the Hansch approach, to their lipophilicity, expressed by Rm chromatographic values. Although all the experimental results show a parabolic dependence, only in few cases the parabolic model calculated by Hansch fits to them. In most cases it was possible to find a good fitting between the ascending side of the parabola and the linear equation of Hansch. The meaning of the results and their utilization for future work are discussed.

Bacteria↗