Biomedical subjects
Publications and source records attributed to A Daly.
177 respondents attending a midwestern state university reported greater alienation from the wider society when they held more positive attitudes than negative ones toward women and homosexuals. Alienation and attitudes toward African-Americans, women, and homosexuals were not influenced by gender or religiosity.
We have isolated DNA probes, homologous to the human hypervariable minisatellite sequence 33.15, from the genome of rice (Oryza sativa). These probes are capable of producing a multilocus rice DNA fingerprint. The rice sequence has a tandem repeating structure based on a 12 bp GC-rich repeat which shows homology to its human counterpart. This probe detects up to 30 loci which are at a number of unlinked chromosomal sites. The GC-rich sequence is invariably associated with an open reading frame (ORF) of unknown function. The ORF is probably a member of a small multigene family.
A 29 year old expectant mother was critically ill at 27 weeks gestation with disseminated metastatic malignant melanoma and was treated with dacarbazine. A dramatic remission was induced and at 38 weeks gestation she went into labour spontaneously and delivered a healthy infant. She relapsed and died eight weeks post partum. This is the first reported use of dacarbazine in pregnancy.
Lactose and casein synthesis by rabbit mammary explants in organ culture was inhibited when fractions of goat milk were included in the culture medium. Inhibition was dose-dependent, and readily reversed when milk fractions were removed. The pattern of effects obtained with various fractions of milk indicated that inhibition was caused by a protein of 10,000-30,000 Da, which was present in the milk serum or whey fraction. The inhibitor fraction decreased milk accumulation when injected into lactating rabbit mammary glands via the teat ducts, whereas other milk proteins had no effect. Results are discussed in terms of autocrine regulation of milk synthesis through negative feedback by milk constituents.
We conducted a study to review the organization of medical care for the 1984 Los Angeles Summer Olympics, to review the spectrum of illnesses encountered by health care providers, to determine the usage patterns of available services, and to assess the role that physicians and other providers play in special event mass medical care. Recorded medical care provided at Olympic venues with a spectator capacity of more than 10,000 (nine of 28 competitive sites) was reviewed retrospectively. Total attendance at these sites during the 15 days of competition was 3,447,807. Of this population, 5,516 (0.16%) were evaluated on site by RNs or MDs. Only 29% required physician evaluation. Common diagnoses (recorded using International Classification of Diseases code) encountered by physicians were minor musculoskeletal and dermal injuries (25%), heat-related illness (12%), and minor gastrointestinal complaints (8%). Two percent of patients presented with symptoms of cardiac disease, and only eight people required physician care for alcohol or drug ingestion. Ninety-one individuals were transferred to hospitals for further evaluation/care; of these, 22 were transferred for musculoskeletal injury and 18 were transferred for suspected cardiac disease. Usage rates (number of patient visits per 1,000 in attendance at each site) ranged from 0.68 to 6.8, with a mean of 1.6, and were higher at venues with multiple daily sessions, outdoor events, and events at which spectators could move about. We found that the majority of medical problems encountered at major athletic events are musculoskeletal, cutaneous, or of an "environmental" nature. The majority of medical problems encountered in our study were managed by appropriately trained and experienced nonphysician health care providers.(ABSTRACT TRUNCATED AT 250 WORDS)
1. Plasma 25-hydroxy-vitamin D concentration was measured in 40 normal subjects, 19 patients with terminal renal failure, 137 patients who had been on dialysis up to 11 years and in 17 renal transplant patients. 2. The mean plasma concentration of 25-hydroxy-vitamin D was below normal in patients with terminal renal failure and in patients who had been on maintenance haemodialysis for less than 1 year. The mean concentration in patients who had been on dialysis for more than 1 year and in renal transplant patients was normal. 3. The seasonal variation of plasma 25-hydroxy-vitamin D concentration found in the 58 patients on maintenance haemodialysis for more than 2 years is similar to that reported in normal subjects.
Evaluations of toxic potential of drugs and chemicals often involve statistical comparisons of effects between treatment groups. Such comparisons are valid and permit elucidation of spontaneous versus treatment effects only if the sampling population is obtained without selection bias. Selection bias is routinely minimized or controlled by random sampling or unbiased allocation of animals to treatment groups. A systematic approach using a computerized procedure is described that fulfills these requirements in a simple and efficient fashion.