Biomedical subjects
Publications and source records attributed to A Danziger.
Myelographic changes after spinal operation are often difficult to interpret especially with regard to the differentiation between arachnoiditis and recurrent disc prolapse. The radiological appearances using iophendylate (Myodil) and the distinguishing features are discussed and illustrated.
Craniopharyngiomas present a diverse appearance on computed tomography. Histological diagnosis is not always possible, but computed tomography is of great assistance in the delineation of the tumour as well as of the degree of associated hydrocephalus. Computed tomography also enables rapid non-invasive follow-up after surgery or radiotherapy, or both.
Forty-two patients with histologically proven orbital tumours are presented. CT is of value in the pretreatment assessment and in delineating the extent of the orbital tumour. The surrounding bony destruction and intracranial extension are easily assessed. Post-treatment follow-up can be closely monitored using CT.
A retrospective study of 133 patients with documented head trauma is presented. Computed tomography (C.T.) has replaced cerebral angiography in the evaluation of these patients at our institutions. C.T. provides a rapid noninvasive diagnosis, plus accurate localization of lesions; it also allows for the assessment of multiple lesions. The authors feel that C.T. should be the first neurological mode of investigation after plain skull radiographs. It is important to obtain good quality scans, and intravenous sedation or general anaesthesia may be required.
Computed tomographic (CT) findings in 38 patients with surgically proven retinoblastomas are described. CT is of value in accurately and rapidly assessing the extraocular and intracranial spread of clinically diagnosed retinoblastomas. This information is of prognostic value as patients with tumors that have spread beyond the confines of the globe have a life expectancy of only a few months. Calcification was present in 11 of 23 tumors confined to the globe, but was seen in only two of 15 tumors that had extended beyond the globe. Therefore, the presence of calcification may be a favorable prognostic sign.
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The computed axial tomographic (CAT) findings in 22 children with intracranial neoplasms are presented. CAT offers a rapid, non-invasive method of assessing the locality and extent of these tumours, as well as the presence of calcification and hydrocephalus. CAT is of value in the follow-up treatment, but an absolute histological diagnosis is not always possible.
Post-radiation cerebral necrosis simulating tumours was found in 2 patients by computerized axial tomography (CAT). The appearance was indistinguishable from that of a recurrent tumour in one patient and a glioma in the second. The significance of the scan findings was only realized after surgery and histological examination. The investigation appears to offer no assistance in differentiating between these conditions.
A retrospective study has been undertaken of patients with intracerebral abscess and subdural empyema. Computerised tomography (CT) offers a rapid, non-invasive mode of diagnosis with accurate localisation and assessment of multiplicity of lesions. We propose that early diagnosis and correctly timed surgical intervention has lessened the mortality rate. CT allows for easy follow-up of patients and has allowed us in one case, to treat an inaccessible abscess conservatively.
Twelve patients with proven tuberculosis were studied by computed tomography. Three had tuberculomas and nine had tuberculous meningitis. Although a definite diagnosis is often not possible on CT, the method is of value in determining number, location and extent of lesions. In patients with tuberculous meningitis, CT is helpful in assessing the degree of hydrocephalus and in evaluating the effectiveness of antituberculous therapy.
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We used the computed tomographic scanner in the assessment of ten cases of retinoblastoma in children. With each patient the stage of the disease before operation could be more accurately defined and therefore more definite treatment could be undertaken.
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