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Biomedical subjects

A Dark

Publications and source records attributed to A Dark.

7 recordsLinked to original sources
PubMed1999

Severe postoperative laryngeal oedema causing total airway obstruction immediately on extubation.

We report a case of total upper airway obstruction occurring immediately after extubation after elective bi-maxillary osteotomy. The obstruction was caused by severe, progressive supraglottic oedema, which totally obscured the laryngeal inlet. No swelling had been present at initial laryngoscopy and intubation. Immediate re-intubation of the patient's trachea was difficult but life saving. Subsequent investigations revealed extensive soft tissue swelling, maximal at the level of the hyoid and extending downwards into the trachea. The cause of such severe oedema in this case is not certain, but may be related to vigorous submental liposuction carried out at the end of operation. We have found no other reports of total airway obstruction occurring immediately after extubation as a result of this cause. We review the appropriate literature, describe the postoperative management and suggest precautions in similar patients.

Adult↗
PubMed1982

A double-blind randomized trial of low-dose oral urea to prevent sickle cell crises.

Seventy-nine homozygous SS patients were randomly assigned to control or oral prophylactic urea treatment in a double-blind trial designed to determine whether prophylactic oral urea, in low doses, prevents sickle cell crises. The average follow-up time for these patients was 13.7 months and 33 patients were diagnosed as having one or more crises during the study. No statistically significant treatment differences were found in weight changes, bilirubin changes, or hemoglobin changes over the course of the study or in the distribution of time to first crises or time to second crisis. This study gives no evidence in favor of the hypothesis that prophylactic oral urea, in low doses, prolongs time to crisis.

Administration, Oral↗