Biomedical subjects

A Davis-Daneshfar

Publications and source records attributed to A Davis-Daneshfar.

3 recordsLinked to original sources

PubMed1996

No detection of HTLV-I proviral DNA in lesional skin biopsies from Swiss and German patients with cutaneous T-cell lymphoma.

The search for an infective agent linked to cutaneous T-cell lymphoma (CTCL) has also included the human T-cell lymphotropic virus type I (HTLV-I). Using sensitive techniques such as Southern blotting under low stringency conditions of hybridization and polymerase chain reaction (PCR) with primer sets designed to match pol, env and pX sequences of HTLV-I, we have screened lesional skin biopsies of 50 Swiss and German patients suffering from CTCL. No evidence of proviral integration of HTLV-I could be demonstrated in any of our patients. Our results, as well as a review of the literature, indicate that at least for European patients, HTLV-I does not seem to play a role in the aetiology of CTCL.

Base Sequence↗

PubMed1995

[Strategies for gene therapy of melanoma].

Active unspecific immunotherapy in an adjuvant or palliative setting has been shown to enhance survival in melanoma patients, and gene therapy now offers new perspectives for active specific immunotherapy. Gene therapy includes the transfer of genetic material performed by either viral or non-viral methods and in vivo or ex vivo. For melanoma the following approaches are suggested: vaccination with tumour-specific, HLA-associated antigens using peptides or 'naked DNA', vaccination with melanoma cells transfected with cytokine genes or B7, adoptive immunotherapy with specific T-lymphocytes or transfected tumour-infiltrating lymphocytes, or transfection of tumour cells with a tumour suppressor gene whose dysfunction plays a crucial role in melanoma.

Cytokines↗

PubMed1995

[Tonsural trichotillomania].

Tonsure trichotillomania is a subtype of trichotillomania in which the scalp exhibits a tonsural pattern of alopecia over the crown, extending to the frontal margin and sparing the lateral margins and the nape of the neck. It differs from the more common form of childhood trichotillomania in that predominantly female adolescents are affected and its incidence is related to quite severely pathologic psychodynamics, often with a disturbed relationship to female sexuality. The treating physician should be more guarded in assessing the prognosis; hair plucking often continues for years. Two patients with tonsure alopecia, associated in one case with trichotillomania of the pubic hair and in the other with enuresis, are presented.

Adolescent↗