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A De Maria

Publications and source records attributed to A De Maria.

70 records · Page 4Linked to original sources
PubMedDate not supplied

Intraperitoneal infusion of interleukin-2 in patients with malignant ascites: phenotypic and functional effects on tumor-associated lymphocytes.

The aim of the present study was to evaluate the effects of intraperitoneal interleukin-2 (IL-2) infusion on tumor-associated lymphocytes (TAL) and peripheral blood lymphocytes (PBL) in patients with malignant ascites. Six patients were given IL-2 daily for 14 days by intraperitoneal infusion using a delivery system. TAL were isolated from the ascitic fluid before (day 0) and 7 and 14 days after the initiation of the treatment. Although no variations were observed in cytolytic activity and surface markers of PBL, TAL showed an important increase in the percentage of cells expressing IL-2 receptors of lymphokine-activated killer (LAK)-1 antigen (i.e., a surface molecule expressed by human LAK cells and their precursors). Perhaps more importantly, a sharp increase of natural killer activity and the de novo generation of LAK activity were also observed.

Ascites↗
PubMedDate not supplied

[Hürthle-cell thyroid neoplasms: a clinical enigma].

Hürthle cell neoplasms represent a pathological entity whose diagnosis and therapy are still not defined. These neoplasms constitute from 1.5% to 10% of all thyroid tumors. Hürthle cell nodule is clinically indistinguishable from other nodular thyroid diseases and histologic features of the tumors do not always allow us to distinguish benign nodules from malignant ones. The authors, analyzing a segment of their own experience (335 surgical thyroid diseases), observed nine cases of Hürthle cell adenomas (0.03%). Because of concomitant presence of heterolobar thyroid disease, seven cases were treated with a total thyroidectomy, and two cases were treated with a lobo-isthmectomy. In a long-term follow-up study, there were not signs of Hürthle cells neoplastic disease. The authors suggest that the treatment of choice for patients with "surely benign" Hürthle cell nodule is lobo-isthmectomy. For malignant Hürthle cell tumors, total thyroidectomy is the most rational treatment associated with cervical lymphadenectomy in presence of metastatic nodes. In all cases, a long-term periodical check-up proves to be the best solution, also for patients treated for benign pathological Hürthle cell.

Adenoma, Oxyphilic↗
PubMedDate not supplied

[A case of breast metastasis in bladder urothelioma].

A case of isolated mammary metastasis from surgically untreated urothelial vesical carcinoma is discussed. An integrated chemo-radiotherapeutical treatment had been planned, due to bad general condition; after this, an optimal subjective benefit and good objective response (reduction in lesion diameter < 50%, MR) were obtained. An isolated breast lesion appeared ten months after; its metastatic nature was only indirectly suspected by mammographic and echographic features. Only immunohistochemical study, realized on percutaneous needle biopsy specimen, definitively confirmed the urothelial metastatic origin. In present work, biological and prognostic significance of mammary metastases and the needing of distinguishing them from primary breast neoplasm are analysed, basing on the literature review.

Aged↗
PubMedDate not supplied

HIV infection in a male patient with systemic lupus erythematosus.

The association between systemic lupus erythematosus and human immunodeficiency virus infection is extremely rare. We report a case of this association and discuss the possible reasons for its rarity, together with the difficulties encountered in the interpretation of the clinical and laboratory features.

Acquired Immunodeficiency Syndrome↗