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Biomedical subjects

A DeSimone

Publications and source records attributed to A DeSimone.

6 recordsLinked to original sources

Alcohol use, self-esteem, depression, and suicidality in high school students.

In this study of both high school and college students under 21 years of age, it was found that alcohol use and misuse was positively associated with depression, as expected, but also with self-esteem, opposite to what was expected. It was also found that alcohol use and misuse were associated with depression in college students 21 years of age and older.

Adolescent

Tocainide: a severe adverse reaction.

Tocainide is a primary analog of lidocaine with antiarrhythmic properties used to treat ventricular rhythm disorders. A 76-year-old man with benign paroxysmal premature ventricular contractions was treated with tocainide and developed a generalized maculopapular lupoid eruption, bleeding from the lips and gingivae, vertigo, gross tremors of the extremities, fever, and short-term memory loss, which required hospitalization. The patient recovered slowly over three months with no permanent sequelae after discontinuing the drug and receiving rigorous supportive care. His excellent physical status and absence of concomitant illness contributed to an uneventful recovery. Tocainide is a potent cardioactive drug with a long biological half-life and should be used with caution.

Aged