[Comparison of tolerability and clinical efficacy of acetylsalicylic acid and a new nonsteroid anti-inflammatory drug in osteoarthritis].
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Biomedical subjects
Publications and source records attributed to A Debolini.
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The authors have studied the incidence of hepatitis associated antigen (HAA) and the homologous antibody in sera of patients with rheumatoid arthritis on the basis of (1) arthritis sometimes associated with viral hepatitis, (2) the possible infectious etiology of rheumatoid arthritis, and (3) observation on the possible pathogenetic role of HAA in some cases of polyarteritis nodosa. The presence of HAA and antibody titer gave constantly negative results in all subjects examined with the exception of one case which showed no signs of serological or histological hepatic involvement. On the basis of the results obtained, the negligible role of HAA in the etiopathogenesis of rheumatoid arthritis is underlined. However, the authors emphasize as suggestive the hypothesis that the characteristic histopathological alterations of rheumatoid arthritis may be mediated by an immunological reaction toward an infectious agent other than HAA, but operating through mechanisms similar to those of HAA in polyarteritis nodosa.
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The AA. carried out an epidemiological survey on 1,420 cases with viral hepatitis ascertained in the Province of Siena during the period January 1, 1962-December 31,1972. Age, sex, profession, place of origin, annual and seasonal prevalence, therapeutic measures, geographic and social-economic features of several districts, and other characteristics of the affected people were examined. The results obtained were discussed keeping in mind the various parameters examined.