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Biomedical subjects

A Deiss

Publications and source records attributed to A Deiss.

13 recordsLinked to original sources
PubMed1997

Spurious hypophosphatemia in a patient with multiple myeloma.

We report a patient with multiple myeloma and a prolonged history of hypophosphatemia who had remained asymptomatic. Extensive evaluation for a cause, including the search for a renal tubular disorder, oncogenous osteomalacia, or a parathyroid hormone (PTH)-related protein was unproductive. Renal biopsy showed no evidence of myeloma kidney. Subsequent mixing of the immunoglobulin G (IgG) fraction from the patient's serum with normal human serum, confirmed that the observed hypophosphatemia was spurious, resulting from interference of large amounts of an abnormal IgG with a standard automated laboratory assay for phosphate.

Autoanalysis↗
PubMed1983

Iron metabolism in reticuloendothelial cells.

Metabolism of iron within cells of the RE system is less well understood than any other aspect of iron metabolism. Only with respect to the activity of microsomal heme oxygenase does any precise knowledge exist. Sequestration, phagocytosis, control of iron movement into and out of storage pools and between storage substances, regulation of release, and disturbances in disease states can only be discussed in broad outline. The absence of precise information is reflective of the difficulties inherent in studying the system. Interpreting data obtained from various animal models has been difficult, in part perhaps because subtle differences in the behavior of RE cells in different organs tend to blur outcomes which might be clearcut if uniform populations could be studied. Efforts to control these variables by employing cell cultures of various origins have been reported, 19,22,39,60,65,66,93 but there has been no systematic use of such in vitro models. Regardless of how the RE system is studied, however, it seems likely that until the assumptions upon which a model is based are thoroughly understood, little useful information can be expected.

Absorption↗
PubMed1975

Hematologic changes in chronic arthritis of mice induced by Mycoplasma arthritidis.

The arthritis caused by iv injection of M. arthritidis in mice was found to be associated with neutrophilia and lymphopenia without a change in the total WBC concentration. A mild anemia developed which was characterized by hypoferremia and plentiful RE iron but with an increased plasma total iron-binding capacity. This anemia therefore differs from the anemia of chronic disorders and indeed from any anemia which occurs in man.

Anemia↗
PubMed1970

Ferritin metabolism in reticulated-siderocytes.

Reticulated-siderocytes (reticulocytes which contain siderotic granules), obtained from the circulation of pigs after vigorous phlebotomy, were incubated in vitro. A rapid disappearance of granules from the reticulocytes was observed over 24 hr. Simultaneously with the decrease in granules, soluble ferritin accumulated in the media and siderotic granules developed in monocytes. The disappearance of the granules from the reticulated-siderocytes was oxygen-dependent and the loss of granules and the accumulation of ferritin in the media were both prevented by the addition of cyanide or dinitrophenol. It is concluded that the ferritin aggregates in the granules of reticulated-siderocytes are dispersed intracellularly into soluble ferritin, that soluble ferritin is excreted from the cell, and that one or both of these steps is dependent upon oxidative metabolism. Blood monocytes are capable of taking up soluble ferritin from the media and converting this into siderotic granules. Thus, a reticulocyte to plasma to monocyte ferritin pathway has been described.

Animals↗