[FANS: what should the patient know?].
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Analgesics, Non-Narcotic↗
Biomedical subjects
A Del Favero
Publications and source records attributed to A Del Favero.
A double-blind study comparing two single-dose regimens of ketorolac with diclofenac in pain due to cancer.
STUDY OBJECTIVE: To compare the analgesic efficacy and safety of two single doses of ketorolac with diclofenac in acute cancer pain. DESIGN: Double-blind, randomized, clinical study. SETTING: Hospital-based clinical research center. SUBJECTS: One hundred eighty patients suffering acute, moderate, or severe cancer pain. INTERVENTIONS: A single intramuscular injection of ketorolac 10 or 30 mg or diclofenac 75 mg. MEASUREMENTS AND MAIN RESULTS: Pain intensity was assessed 30 minutes and 1, 2, 3, 4, 5, and 6 hours after injection or until rescue drug administration. In approximately 70% of patients all treatments provided prompt sustained pain relief throughout the 6-hour observation period. There were no statistically significant differences in any of the analyzed efficacy measures among the three groups. CONCLUSION: Intramuscular ketorolac 10 mg is adequate to relieve cancer pain, and is equivalent to ketorolac 30 mg and to diclofenac 75 mg.
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