PubMed Health⌕ Search

Biomedical subjects

A Delgado-Iribarren

Publications and source records attributed to A Delgado-Iribarren.

14 recordsLinked to original sources

[Intravenous drug users serologic control: what may be prevented?].

OBJECTIVE: To report of IDU serologic control done in 1997 in comparison with another of 1990, in a Health-Care Area of Madrid, Spain, focussing to hepatitis B virus prevention. PATIENTS AND METHODS: Cross-sectional study. LOCATION: Fuenlabrada-Leganés, 400,000 inhabitants Health-Care Area in the Southeast of Madrid. PATIENTS: 233 IDU submitted for serological study during 1997 (mean age, 29.5; standard deviation, 6.8; 85.8% males). INTERVENTIONS: HIV, HBV, HCV and Treponema pallidum; serological markers were done at Severo Ochoa Hospital and a search for previous reports since 1991. Study of HBV previous vaccination was done with HBsAb marker in HBV seronegative patients. RESULTS: Prevalence: HBV 39.5% (IC = 33.2-46.1), HCV 49.3% (IC = 42.8-55.9), HIV 11.1% (IC = 7.5-16.1), syphilis 3.4% (IC = 1.5-7). Statistically meaning falls in rates were detected comparing them with results from 1990 (HBV: 67.5%; HCV: 75.1%; HIV: 50.1%; n = 261; p < 0.001). Only 5 (3.55%) out of 141 HBV seronegative patients showed HBsAb titres above 10 mU/I, although 55 (39%) of them had been tested for HBV previously. Nineteen (20.6%) out of 92 patients with HBV markers had previous seronegative reports and 3 of them suffered an acute viral infection. CONCLUSIONS: We have seen a statistically meaning fall in seroprevalence of the studied agents although a low HBV vaccination rate was achieved.

Adult↗

[Factors of pathogenicity, biotype, serotype and antimicrobial sensitivity of 150 clinical isolates of Yersinia enterocolitica (1992-1994)].

BACKGROUND: Yersinia enterocolitica is an important pathogen in temperate climates. The heterogeneity of the microorganisms covered by this denomination has a made grouping and identification schemes necessary. METHODS: A series of 150 different, consecutive isolates from patients with diarrheic syndrome living in an urban area with a population of approximately 500,000 inhabitants, were studied in order to evaluate their biochemical, antigenic and sensitivity characteristics. RESULTS: There was a high degree of uniformity among the strains isolated, 144 (96%) of which were identified as Yersinia enterocolitica sensu stricto, biotype 4, serotype 0:3. These strains presented, almost invariably, the same susceptibility pattern, being sensitive to amoxicillin/clavulanic acid, piperacillin, cefamandole, cefoxitin, gentamicin, amikacin, tetracycline and cotrimoxazole, and highly resistant to ampicillin, ticarcillin and cephazotin. In addition, 5 strains of Yersinia frederiksenii were isolated. The biochemical, epidemiological and sensitivity characteristics of these strains differed from those invariably found in the rest of the isolates. CONCLUSIONS: The data obtained in this study, shown a high degree of uniformity in the strains of Yersinia enterocolitica isolated in our area in recent years, with regard to both their biochemical characteristics and their sensitivity patterns. The isolations of the other biogroups may be regarded as extremely infrequent in the stool culture of patients with diarrhea treated in our hospitals.

Bacterial Typing Techniques↗

[Infection by HIV and the hepatitis B, C, and D viruses in intravenous drug addicts. Seroprevalence at 1 year and its follow-up].

BACKGROUND: The aim of the present article was to study the serology of intravenous drug user patients against the hepatitis B, C, D, and HIV, during 1990 and the follow-up during the same year, and 1991. METHODS: A study of 265 patients (mean age: 25 years, range: 16-45; 206 males and 59 females) was carried out. Forty-two percent came because of detoxication treatment, 30% requested diagnosis for hepatic disturbances and the only data provided in 28% were that they were intravenous drug users. None of the patients was an inmate from prisons. RESULTS: Seroprevalences were 67.5% for the HBV, 75.6% for HCV, 17% for HDV and 50.2% for HIV. In the patients seronegative for HBV (65%) and HIV (58%) no new serologic controls were performed during the study period, while in those who underwent controls the rates of seroconversion were 43.3% and 32%, respectively. In 30% of all seroconversions to HBV coinfection with HDV was found and in 23% antibodies against HIV were observed. CONCLUSIONS: Due to the high rates of infection obtained, the authors believe that serologic follow up of intravenous drug users is advisable.

Adolescent↗

Epidemiology of aerobactin production in Enterobacteriaceae.

Clinical isolates (496) of 10 different enterobacterial genera were studied for aerobactin excretion, colicin production and antibiotic resistance. In the case of Escherichia coli, the incidence of aerobactin-positive strains in 108 blood isolates (45%) was not significantly different from that corresponding to faecal sources (41%). Although colicin V production was much more frequently associated with aerobactin production than other colicins, colicin V was only produced by 26% of aerobactin excreters. Some strains were aerobactin-negative and colicin V producers. Aerobactin production seemed to be significantly associated with plasmidic antibiotic resistance. The production of the siderophore is described for the first time in Proteus, Serratia and Morganella strains.

Blood↗