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Biomedical subjects

A Della Puppa

Publications and source records attributed to A Della Puppa.

12 recordsLinked to original sources
PubMed2002

Tracheal esophageal combitube: a useful airway for morbidly obese patients who cannot intubate or ventilate.

The tracheal esophageal combitube has been successfully used in many difficult airway circumstances. We report the dramatic case of a morbidly obese patient with a well-known difficult airway who was successfully rescued from a cannot ventilate-cannot intubate situation in our critical care unit by using the tracheal esophageal combitube. Surgical tracheostomy was performed while she was mechanically ventilated through the tracheal esophageal combitube. The tracheal esophageal combitube is a very important device that should be kept available in all cases of morbidly obese airway management.

Esophagus↗
PubMed1994

[Use of pulse oximetry in the diagnosis of accidental bronchial intubation during laparoscopic surgery. Description of a clinical case].

In the present article a case of accidental bronchial intubation during laparoscopic cholecystectomy is described. Endotracheal tube was probably displaced by gas distension of the abdomen during laparoscopy. Indeed, under these circumstances, carina may move cephalad. Initially, tube displacement was not diagnosed by either auscultation of breath sounds, or ETCO2 monitoring. Instead, a decrease in arterial oxygen saturation, as monitored by pulse oximetry, quickly allowed diagnosis and correction of the problem. It is concluded that pulse oximetry is more sensitive than other methods in providing early warning of tube displacement during laparoscopy.

Aged↗
PubMed1989

Involvement of nigrotecto-reticulospinal pathways in the iminodipropionitrile (IDPN) model of spasmodic dyskinesias: a 2-deoxy-D-[1-14C]glucose study in the rat.

Chronic administration of iminodipropionitrile (IDPN) to rats causes a persistent behavioral syndrome characterized by lateral and vertical head twitches, random circling, and increased tactile and acoustic startle responses. In order to identify brain areas which are affected in rats manifesting this syndrome, we used the autoradiographic 2-deoxy-D-[1-14C]glucose ([14C]DG) method to map cerebral glucose utilization in IDPN-treated rats. One day after the development of the dyskinetic syndrome, there were significant decreases in local glucose utilization in the substantia nigra pars reticulata (SNr) and compacta (SNc), the dorsal raphe, the superficial and deep layers of the superior colliculus, the inferior colliculi, the interpeduncular nucleus, the medial and dorsolateral geniculate nuclei, and the superior and lateral vestibular nuclei. There were also significant decreases in layer 2 of the cingulate cortex and in the temporal and occipital cortices. In contrast, there were no changes in the motor cortex, the caudate-putamen, the nucleus accumbens, or the median raphe. These findings suggest that deleterious effects of IDPN on the nigrotectal pathways which affect head and neck movements and circling behaviors via the brainstem reticulospinal tracts may play an important role in the IDPN-induced persistent spasmodic dyskinetic syndrome in rats.

Animals↗
PubMed1989

Caffeine sensitivity of sarcoplasmic reticulum of fast and slow fibers from normal and malignant hyperthermia human muscle.

We have carried out a comparative study of caffeine sensitivity of the sarcoplasmic reticulum (SR) of fast and slow normal human fibers chemically skinned. Human slow-fiber SR is more sensitive to caffeine than fast fiber SR; however, it releases less calcium and at a lower rate than the SR of fast fibers when exposed to threshold concentrations of caffeine. These results indicate that the SR calcium release mechanisms of SR of fast and slow human fibers are homologous but not identical. An increased sensitivity of SR to caffeine is found in both fast and slow fibers from human malignant hyperthermia muscle. However, fast fibers seem to be the most affected, since their caffeine threshold for contraction is very close to that of slow fibers.

Caffeine↗
PubMed1989

Time course of verapamil interaction with morphine effects on physiological parameters in rats.

The effects of subcutaneous doses of morphine and verapamil on respiratory and cardiovascular parameters have been assessed in conscious rats. Verapamil (10 mg kg-1) was injected simultaneously with morphine (16 mg kg-1) or at 10, 30, or 60 min before morphine administration. Morphine induced respiratory depression, as indicated by marked hypercapnia, hypoxia and acidosis, and caused marked tachycardia. Although morphine produced only a minor and inconsistent (but statistically significant, P less than 0.01) reduction of mean arterial blood pressure, morphine potentiated verapamil-induced hypotension. Verapamil suppressed morphine-induced hypercapnia only when injected simultaneously with morphine. Verapamil alone did not affect arterial blood gases or pH, but decreased heart rate and mean arterial blood pressure. Verapamil attenuated and delayed the maximum positive chronotropic effects of morphine at all times tested. Antagonism by verapamil of respiratory depression and tachycardia produced by morphine was unrelated to morphine levels in plasma. Thus, the explanation of verapamil-morphine interactions on respiration and cardiovascular function is not pharmacokinetic.

Animals↗