[Evolution of early manifestation of peripheral arterial occlusive disease--the fate of survivors].
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Arterial Occlusive Diseases↗
Biomedical subjects
A Delley
Publications and source records attributed to A Delley.
Fibrinogen, factor VIII related antigen, antithrombin III and alpha 2-antiplasmin in peripheral arterial disease.
In 306 subjects, 217 without and 89 with peripheral arterial disease (PAD), VIIIR:Ag and alpha 2-antiplasmin are significantly higher in PAD (p less than 0.01). In the PAD negative group the ratio alpha 2-antiplasmin/antithrombin III activity is significantly higher 1.11 +/- 0.3 in the patients with an abnormal exercise ECG typical of coronary disease than in normal subjects 1.02 +/- 0.2 (p less than 0.05). In the PAD positive group antithrombin III concentration is higher in patients with a normal exercise ECG than in patients with abnormal exercise ECG (p less than 0.05). The same is true for alpha 2-antiplasmin but not for the antithrombin III activity. Fibrinogen and VIIIR:Ag are higher in patients with a previous myocardial infarction, however, the age is also significantly different as compared to the group without previous myocardial infarction. Disturbance of the cerebral arterial circulation is characterized by an elevation of VIIR:Ag and of alpha 2-antiplasmin as compared to the values obtained in patients without this complication. There is a general tendency towards higher alpha 2-antiplasmin values with the extension of the arterial disease.
Antigens↗
[The importance of peripheral-arterial occlusive diseases in medical practice. Conclusions from the Basel study].
Based on prospective epidemiological studies, tentative conclusions concerning the place of occlusive peripheral artery disease ( OPAD ) in general practice are presented. For men aged 35-64 the 5-year incidence of OPAD was found to be 76%, i.e. 3 times higher than that of intermittent claudication. In a high percentage of cases new occurrences of OPAD were predictable by the risk profile at entry. Men with 3 risk factors had an incidence of 114% compared to 20% in those free of risk at entry. A comparative 11-year follow-up of 273 men with OPAD and 273 age-matched, randomly selected controls without OPAD , revealed a moderate incidence of local complications (3% amputations) but an impressive excess mortality of 33% vs 11%, mainly due to coronary heart disease. The high correlation between the risk profile on the one hand and morbidity/mortality on the other emphasizes the need for action against risk factors. The efficacy of measures for the improvement of the risk profile and the reduction of cardiovascular mortality is discussed on the basis of the so-called " Mister Fit Study".
Adult↗
[Pigment formation in photocoagulation lesions of the retina--biomicroscopic observations (author's transl)].
Retinal changes following photocoagulation (argon laser, xenon coagulator) were documented biomicroscopically in 31 patients who were studied prospectively for 90 days following treatment. Older photocoagulation scars were examined retrospectively in another 15 patients. The purpose of the study was to evaluate a possible new formation of pigment in the pigment epithelial layer. In most patients new pigment first appeared in the lesions two to three weeks after coagulation. The amount of pigment increased more and more slowly with time, but did not stop until the end of the observation period. Different forms of scar formation were observed, such as severe pigmentation, pigmentation outside the coagulated area, scars with glial components, but also extraretinal effects and effects on the retinal surface far from the coagulated area.
Cicatrix↗
[Varices, a true disease?].
There is little agreement on the real prevalence and significance of varices of the lower limbs. The discrepancies between the data produced by the various studies are attributable to several factors, of which the most important has to be the absence of any definition of the forms and types of varices. In the Basle study there has been an attempt to classify into two groups, "disorder" and "disease", according to the severity of the clinical picture. These two groups are clearly distinct regarding complications and the number of risk factors. A study on the long-term development has also shown that at the end of 11 years the group "disease" more frequently presented socio-medical after-effects than the group "disorder". Pronounced varices therefore do constitute a real disease and merit appropriate attention.
Female↗