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A Delpech

Publications and source records attributed to A Delpech.

64 records · Page 4Linked to original sources
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[Methods for study of soluble antigens in pathological anatomy].

The authors restate their personal researches about several antigen systems, viz. ACE, neurospecific antigens. They point out the complementarity of immunochemistry and immunohistochemistry which implicates a very precise methodology and utilization of rigorously monospecific immune serums with regard to the studied antigen. This conduces to reproducible, responsive and reliable techniques in optic microscopy but much less easily so in electron microscopy. These techniques are still partly experimental; but their application to the study of pathological tissues and especially of tumors may however be considered. The identification of histological types and the correlated evolution is suggested on hand of concrete examples.

Adenocarcinoma↗
PubMedDate not supplied

[Immunocytochemical localization of gliofibrillary proteins (GDAP) in human cerebral tumors. Histological and in vitro studies].

On the basis of studies utilizing antibody to GFAP (glial fibrillary acidic protein) in the indirect immunofluorescent and immunoperoxydase methods we report the presence of GFAP in 5 astrocytomas, 1 ependymoma and 1 medulloblastoma. The GFAP was evidenced on cryostat sections of frozen material and in short-term tissue culture. Five others tumors including 1 oligodendrocytoma, 1 choroid-plexus papilloma, 1 meningioma and 2 secondary sarcomas were negative. Possible applications of antibodies to GFAP for localization and therapy of brains tumors were considered.

Antigens↗
PubMedDate not supplied

[Arion's cerclage].

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Anesthesia, Local↗
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[Thyroid pathology and lymphoproliferative diseases].

Four cases are reported, of an association between a thyroidal illness (1 hypothyroidism, 3 hyperthyroidism) on one hand, and a lymphocytic proliferation and/or monoclonal gammapathy on the other. The following findings: HLA B8 or DrW3 in 3, antithyroid antibodies at a very high level in 2, and thyroid stimulating immunoglobulin in 2 support the conclusion of thyroidal diseases of auto-immune nature. Simultaneous appearance of both thyroidal and hematologic illness favors the hypothesis of a non coincidental association. A direct thyroidal activity of the monoclonal paraprotein has been found only once among the 4 published and our 2 cases in which it has been studied. A more likely link would be a common physiopathology: a functional deficiency of T suppressor lymphocytes allowing the proliferation of a cellular clone producing an abnormal immunoglobulin, would also allow the development of a thyroidal illness when favored by a genetic predisposition.

Aged↗