PubMed Health⌕ Search

Biomedical subjects

A Destito

Publications and source records attributed to A Destito.

At least 37 records · Page 2Linked to original sources
PubMed1988

LH-RH analogue treatment for advanced prostate cancer.

The trial drug was ICI 118.630 (Zoladex). Inclusion criteria were histologically confirmed advanced prostate cancer (T greater than 2 or N+ or M+), life expectancy greater than 3 months, and no previous radiotherapy, orchiectomy, or chemotherapy. Treatment started in November 1984; 30 patients were recruited. The period of treatment ranged from 6 to 144 weeks (median of 59.5 weeks). One patient died after 6 weeks of rapidly progressive renal failure. Data were updated to the end of August 1987. The mean age was 67.9 years (53-83 years). Subjective response was evaluated by a mean symptoms score (using daytime micturition, nocturia, dysuria, hesitancy, and flow) and a score of three different items: patients' activity, bone pain, and use of analgesics. Only 7.1% of the patients showed a permanent positive response. Four different objective responses (complete, partial, stable disease, and progression) were possible after evaluating the T category, tumor dimensions, metastases, and prostatic acid phosphatase. Testosterone (T) and plasmatic LH levels rose after administration: T dropped below the castration level (1 ng/ml) within a few days and remained constantly low. The rate of progressive disease was 27.6%; disease control was possible in 72.4% of the patients (PR or SD).

Aged↗
PubMed1985

Ileocaeco-urethroplasty after total cystectomy for bladder cancer.

Eleven cases of ileocaeco-urethroplasty, performed over a 2-year period, are presented. The patients had low grade bladder cancer infiltrating into but not extending beyond the muscle layer (B-T3a). Following radiotherapy a total cystectomy was performed up to the verumontanum; afterwards the prostatic cuff was anastomosed to an ileocaecal segment. The patients have been followed up for 13 to 39 months. One died from metastases after 30 months. The others are alive and in good psychological condition, with satisfactory micturition. We believe this surgical option deserves more careful consideration.

Aged↗
PubMed1984

[Analysis with immunofluorescence of antibodies attached to bacteria in urinary sediment in the diagnosis of the site of urinary infections].

The authors assess the sensitivity and specificity of the antibody-coated bacteria assay for the localization of urinary tract infections. The results are compared with those obtained from cultures of urine samples taken from the upper tract either by ureteral catheterization or by direct puncture of the renal pelvis. In upper urinary tract infections the research of total immunoglobulins has proven positive in 71.4% of the cases; of the IgA class in 71.4%; of the IgG class in 57.1%; of the IgM class in 28.6% and of the secretory component of IgA in 60% of the patients. In case of lower urinary tract infections the research of total immunoglobulins was positive in 25% of the cases: that of the IgA class in 8.3%; of the IgG in 25%; of the IgM in 25% and of the secretory component of IgA in 22.2% of patients.

Diagnosis, Differential↗
PubMedDate not supplied

Anatomo-functional considerations on venogenic impotence.

The authors report their clinical experience with cavernosography and cavernosometry on impotent patients. The indications of method and its correct place in the diagnostic workup are underscored. The methods of evaluation are described, highlighting the advantages of a diagnostic pharmacological approach in respect to a near as possible physiological haemodynamic evaluation. Finally they propose a future development for the method, such as the use of PGE1 instead of the commonly employed drugs, and a new classification for the veno-occlusive disease with stage and grade.

Alprostadil↗