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Biomedical subjects

A Dickson

Publications and source records attributed to A Dickson.

28 records · Page 2Linked to original sources
PubMed1977

Further observations on the incidence and properties of lymphocytotoxins in leukaemia.

54 our of 112 patients with leukaemia have been shown to produce a lymphocytotoxin in their serum when the number of malignant cells present in the peripheral blood was considerably raised but the normal blood cells were low. This lymphocytotoxin reacts with all normal cells. It is a high molecular weight protein, though not an antibody. Partial purification was achieved by elution from DEAE-52-cellulose at about pH 6.9.

Chromatography, Ion Exchange↗
PubMed1975

A raised incidence of HL-A2 plus HL-A9 and other anomalies of the HL-A antigens of patients with leukaemia.

In 54 patients with leukaemia a raised incidence of HL-A9 was noted as well as a markedly increased association between this antigen and HL-A2. This occurred most frequently in patients with chronic myeloid leukemia. As HL-A2 and HL-A9 are both antigens of the first series it has been suggested that all the predisposition to develop leukaemia is controlled by a recessive gene closely linked to the first LH-A locus and in a linkage disequilibrium with HL-A2 and HL-A9. 5 patients also showed definite changes between antigens of the same series, whilst other suffered a partial or total loss in antigenicity. Lymphocytes from 145 controls did not behave in this way, though other patients receiving radiotherapy also 'lost' antigens. So it was postulated that such changes resulted from the treatment of the disease rather than the disease itself.

Gene Frequency↗
PubMed1972

Lymphocytotoxins in leukaemia.

Fifteen out of 51 patients with leukaemia have produced a lymphocytotoxin in their serum which reacts with their own and a high percentage of all other lymphocytes. This is probably a protein, but not an antibody. It has been detected only before or early during cytotoxic treatment, or during a relapse. It is postulated that the lymphocytotoxin is a specific protein produced by the leukaemic cells, which may facilitate their spread in the body.

Antilymphocyte Serum↗
PubMedDate not supplied

Clinical staff development: a two-way solution.

This paper explains how a trust worked with a higher education institution to provide continuing education for clinical staff. The result was a staff development award that carries 60 CATS points at level 2. Evaluation shows that the award has not only helped staff in their practice but has also been cost-effective. In addition there have been benefits in terms of professional development for staff involved in running the programme.

Education, Nursing, Continuing↗