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Biomedical subjects

A Dinan

Publications and source records attributed to A Dinan.

3 recordsLinked to original sources

Hyperpyrexia associated with fatal paramethoxyamphetamine (PMA) abuse.

Investigation of a suspicious death became confused when apparently contradictory findings arose on examination of the body. Subsequent identification of amphetamine abuse including PMA resolved these issues. The reported case highlights some atypical features which may cause difficulty in this small but increasing group of deaths. Three rapid deaths attributed to PMA have been identified in Adelaide in the 12 months before June 1996.

Adult↗

Improved micro-radioimmunoassay of digoxin in serum, with use of 125I-labeled digoxin.

A micro-radioimmunoassay of 125I-labeled digoxin is described in which 10-mul rather than 50-mul aliquots of sera are required. The method is a modification of a simplified, rapid, and accurate procedure, which is commercially available as a kit. There is excellent correlation between results by these two methods, in which lyophilized digoxin standards and insoluble antibody polymer are used. The digoxin concentration in capillary sera was not significantly different from that in the corresponding venous blood. It is clinically useful to monitor digoxin therapy in capillary sera, particularly in patients in whom blood sampling by venipuncture is inconvenient or difficult.

Digoxin↗