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Biomedical subjects

A Ditchfield

Publications and source records attributed to A Ditchfield.

4 recordsLinked to original sources
PubMed2006

Extrapontine myelinolysis presenting as acute parkinsonism.

BACKGROUND: Extrapontine myelinolysis presenting with extra pyramidal features suggestive of parkinsonism may be a challenging clinical syndrome. Clinicians should maintain their vigilance while correcting electrolyte imbalances, especially with associated co-morbidity. CASE PRESENTATION: A 41-year-old woman presented with acute parkinsonism like features while on a holiday. This followed slow correction of hyponatraemia after repeated vomiting. MRI changes were suggestive of Extrapontine myelinolysis(EPM). This case is at variance with four previous cases reported in the medical literature in that the patient made a full clinical recovery and the MR changes resolved with symptomatic support alone. CONCLUSION: Extrapontine myelinolysis could make a complete recovery with symptomatic support alone. During hyponatraemia correction, rapid osmotic shifts of fluid that cause hypernatremia, causes myelinolysis rather than absolute serum sodium level. Even gradual correction of hyponatraemia can produce myelinolysis, especially with pre-existing malnourishment, alcoholism, drug misuse, Addison's disease and immuno-suppression. Pallidial sparing is typical of EPM in MRI scans.

Adult↗
PubMed2006

Multiple intracranial aneurysms presenting with epistaxis.

Although epistaxis secondary to rupture of a post-traumatic, false aneurysm is well documented, true intracavernous carotid artery aneurysms presenting with epistaxis are very rare. We present such a case in a patient with multiple aneurysms. The aneurysm was treated by endovascular techniques and the patient made a good recovery. This case highlights the need to distinguish between true and false aneurysms for both diagnostic and therapeutic reasons.

Cerebral Angiography↗
PubMed1986

Analysis of the changes in the proportion of clustered labelled cells in epidermis.

A new cell kinetic approach is presented from which the duration of the S and G2 + M phases can be estimated. The technique involves an analysis of the spatial distribution of labelled cells in sections or sheets of epithelium (i.e. an analysis of clustered labelled cells). The technique is largely independent of the absolute number of labelled cells and hence is not influenced by factors which affect the absolute number of labelled cells. The technique is described and experimental data from dorsal murine skin are presented. The technique has also been simulated mathematically so that the phase durations and their variances could be estimated. The advantages of the technique are: it is technically simple; it provides at least two independent estimates of the phase durations; unlabelled cells need not be counted (compare with LI or PLM analysis); it is independent of variations in the absolute yield of labelled cells, and it is applicable if the LI is low and the S phase is short (where the PLM technique tends to fail).

Animals↗