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Biomedical subjects

A Doĭchinov

Publications and source records attributed to A Doĭchinov.

At least 19 recordsLinked to original sources
PubMed1991

[The use of labelled leukocytes in the diagnosis of traumatic osteomyelitis].

A total of 20 patients with posttraumatic osteomyelitis were investigated with 99mTc- and 111In-labeled leukocytes. Their elevated accumulation in inflammatory zones were detected on scintigrams of 12 patients. Osteomyelitis in 11 of them was confirmed on the basis of routine clinico-laboratory investigations. This method is a highly specific test in the diagnosis of posttraumatic osteomyelitis and in the assessment of the efficacy of its therapy.

Adult↗
PubMed1987

[Incidence of carotid pathology in patients with chronic arterial insufficiency of the extremities].

The frequency of carotid pathology and of some risk factors in the genesis of atherosclerosis was studied in 189 patients. The patients were classified into two groups: group A--58 persons without clinical data for atherosclerosis (conditionally healthy persons); group B--131 patients with chronic arterial failure in the limbs. By means of Doppler sonography a low incidence of carotid pathology was established in group A (3.4%) and a significantly higher incidence in group B (38%). The results were confirmed angiographically. The risk factor were more frequent in group B than in group A. The atherosclerotic process affects simultaneously the peripheral, carotid and coronary arteries. This implies active screening of the carotid arteries in patients with clinically manifested chronic arterial failure in the limbs of with ischemic heart disease. The method of Doppler sonography is the most suitable for that.

Aged↗
PubMed1986

[Changes in the plasma coagulation factors in patients subjected to plasmapheresis].

Eleven patients with immune-complex diseases were studied, that had been subjected to a total of 96 plasmaphereses during the day. The quantitative changes were followed up that developed in the active factors of coagulation after plasmapheresis. The results revealed that the plasma exchange, applied to the patients studied, induced the following changes: For factor I (fibrinogen)--mean = 2.39 +/- 1.19 g% (p greater than 0.005); for factor II (prothrombin)--mean = 55.5 +/- 20.9% (p less than 0.001); for factor V (proaccelerin)--mean = 97.6 +/- 13.8% (p greater than 0.01); for factor VII (proconvertin)--mean = 106.8 +/- 8.0% (p greater than 0.01); for factor VIII (AHG A)--mean = 64.5 +/- 22.7% (p less than 0.01); for factor IX (AHG B)--mean = 51.58 +/- 26.0% (p less than 0.001); for factor X--mean = 46.4 +/- 18.5% (p less than 0.001) and for factor XII--mean = 27.0 +/- 23.8% (p less than 0.001). That should be given consideration for the indications of the patients and their pretreatment for plasmapheresis.

Adolescent↗
PubMed1984

[Attempt to affect hyperlipoproteinemia in patients by long-term anticoagulant therapy].

The antilipidemic drugs potentiate the effect of the indirect anticoagulants and their co-medication is difficult, risky and requires often laboratory checks. That is why the hyperlipoproteinemias were treated with wheat bran in the patients with hyperlipoproteinemia and thrombembolic diseases with anticoagulant therapy. Twenty seven patients, aged from 34 to 71 (average age 44,6 years)--21 males and 6 females were treated. The anticoagulant treatment was conducted with syncumar in 21 and with marcoumar and falithrom in 6 patients. The patients were recommended to take wheat bran in a dose of 15-20 g, three times daily, suspended in liquid foods for the improvement of the tase, in the course of 1 and 1/2 to 2 months after meals. The therapeutic hypocoagulemia remained optimal. The total lipids were reduced with 20,2 per cent, cholesterine--with 23,8 per cent and triglycerols with 25%. The reduction is statistically significant. No complications were observed but light flatulence.

Adult↗
PubMed1981

[Antithrombin III and its role in normal and pathological hemostasis].

The paper is a survey on the latest up-to-date data on the character, determination methods, physiology, pathophysiology and clinical significance of one of most important factors of anticoagulation system--antithrombin III. Its normal activity is of essential importance for physiological hemostasis. It could be reduced via diminished production, increased elimination and intensified consumption, particularly in case of concomitant grave states and diseases. The enhanced activity of antithrombin III, found most frequently in the treatment with indirect anticoagulants, renal transplantations, and application of anabolic steroids, has given no data of clinical importance so far. Numerous of the outlined problems remain still not sufficiently elucidated.

Antithrombin III↗
PubMed1979

[Limits and potentials of modern functional diagnosis of chronic arterial insufficiency of the extremities (CAIE)].

A survey is made of the angiologic methods for ChAIE investigations. The role and the potentialities of some of the non-invasive present-day methods are discussed in details, implemented lately in the clinical practice: determination of muscular Xenon 133 clearance, venous obturation pletismography (VOP) and US Doppler flowmetry. VOP is one of the few methods, enabling the quantitative assessment of the functional state of peripheral circulation. US Doppler flowmetry, as a relatively easy to apply and adequate method for wide clinical application and for scientific investigations, gives a valuable diagnostic information about CHAIE and enables the accurate dynamic control of the vascular-reconcstructive and conservative therapy. An original classification system is proposed for the assessment of the potentialities of the various angiologic methods in ChAIE diagnosties.

Arterial Occlusive Diseases↗
PubMed1977

[Normal hemostatic indices in experimental animals].

On the basis of the studies conducted by the authors on 19 nonbred dogs and 25 rabbits of the strain Cincilla and Belgium giant the normal values of the basis indices of hemostasis were determined: thromboelastography (r+k and ma), amount of fibrinogen, number of thrombocytes, thromoboplastic time, time of recalcification. The obtained data are shown on a table. The obtained data could serve as orienting data in examining hemostasis in dogs and rabbits under various experimental conditions and models for investigating various human pathology.

Animals↗