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Biomedical subjects

A Dobrescu

Publications and source records attributed to A Dobrescu.

At least 19 recordsLinked to original sources
PubMed1993

Viral hepatitis in Bucharest.

A seroprevalence survey of viral hepatitis was conducted in Bucharest, Romania, between April and July 1990 on a systematic sample of 1355 persons drawn from the general population and groups at higher risk of infection. Sera were tested for hepatitis A, B, and C (HAV, HBV and HCV, resp.) markers using an enzyme-linked immunosorbent assay (ELISA) method. The prevalences of HAV and HBV markers were high in all groups. A total of 47% of the adults from the general population and 39.8% of the children aged 0-16 years had at least one HBV marker. Of the pregnant women 7.8% were positive for hepatitis B surface antigen. Among infants (0-3 years of age) living in orphanages, the prevalence of at least one HBV marker was 54.6%. The findings also confirmed that HCV was circulating in Romania. The results are consistent with national surveillance data and confirm that viral hepatitis is a major public health problem in Romania. Preventive measures will have to include HBV immunization of infants, with an appropriately targeted immunization strategy being determined through further epidemiological studies.

Adolescent↗
PubMedDate not supplied

[Antifungals, their potentials, limits and outlook].

A review of the history of antifungal therapy shows that after a long period of empiricism the therapeutic arsenal available for the nowadays practitioner has suffered a spectacular change. Indicated in the topical and systemic treatment of mycoses, their practical use requires experience and responsibility. The impartial analysis of their antifungal benefits refers to such targets as: ergosterol, protein syntheses and mitoses from fungal cells.

Antifungal Agents↗
PubMedDate not supplied

[An analysis of the medical contraindications for poliomyelitis vaccination in a district of the city of Bucharest].

The authors report on the results of the analysis of frequency, motives and possible consequences associated to the medical contraindication of inoculations with TPDV (thermal polio-destroyed virus) during the antipoliomyelitis vaccination in the spring of 1989 in District 3 of Bucharest. The failure share in the first antipoliomylitis vaccination was of 2.2% in the 2,500 children selected: 46 (83.6%) were CIM in one of the inoculations and 9 (16.4%) in both inoculations with TPDV of the vaccination. Infectious acute affections were the most numerous motives (89.1-57.1%) of the medical contraindications of inoculation with TPDV; in 59.6-31.2% of these causes the hospitalization of the cases was necessary. The false contraindications were at the basis of 10.9-42.9% of the medical decisions that contraindicated inoculation with TPDV. Of the children with contraindications at inoculation with TPDV, 41.8% met the risk criteria after the first stage and 12.7% after the second stage of the vaccination.

Child, Preschool↗
PubMedDate not supplied

[An estimate of the index of collective measles immunity among the pupils in 8-year elementary education in 1988-1989 in sector III of the city of Bucharest].

The authors have verified morbidity antecedents in the medical files of 18.5% of the cohort of 47,354 students registered in classes I-VIII in the year 1988-1989 in the III-rd Sector of Bucharest. On the basis of simple hypotheses concerning the post-infectious anti-rubeola immunity, and the post-vaccinal immunity respectively an index was estimated of the anti-rubeola collective immunity of 89.1% a value associated to the risk of transmission of the rubeola infection in this cohort. These observations have permitted the authors to suggest anti-rubeola vaccination of students without documented evidence of anti-rubeola immunity on the one hand, immediately in all the classes (I--VIII) of the present scholar year, and, on the other hand, to vaccinate all the students in the first class, yearly, as an additional measure in the present control anti-epidemic strategy of rubeola.

Child↗
PubMedDate not supplied

[The etiopathogenesis of psoriasis].

In the onset, persistence or aggravation of psoriasis numerous factors are involved. This paper is the result of the investigations carried out on 446 cases of psoriasis admitted to the Dermatological Clinic of Iaşi and 1455 cases admitted to the Dermatological Clinic of Algeria.

Algeria↗
PubMedDate not supplied

[Further comment on the importance of microscopy in clinical microbiology. The argument for the diagnosis of the skin manifestations of histoplasmosis and coccidioidomycosis].

This paper presents two interesting cases: a patient with cutaneous coccidioidomycosis, the first case in Romania, and a female patient with latent histoplasmosis with cutaneous manifestations, periodically reactivated during her pregnancies. The etiological diagnosis problems of these affections in relation with the degrees of competence of the clinical laboratories is discussed. The role of direct microscopic examination in the early and more rapid diagnosis of deep mycoses is underlined.

Adult↗