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Biomedical subjects

A Dobreva

Publications and source records attributed to A Dobreva.

12 recordsLinked to original sources
PubMed1988

[Examination of platelet aggregation and ultrastructure in patients with non-Hodgkin's lymphoma].

Aggregation and secretion reaction of thrombocytes were studied in 54 patients suffering from Non-Hodgkin's++Lymphoma. Results were compared with electron-microscopic findings on thrombocytes of the same patients. Slight changes were found in stage II. In stage IV distinct therapy-resistant changes were noted in combination with storage pool disease syndrome which is to be considered as a consequence of impaired generation of thrombocytes in bone marrow.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[Thrombocyte functions in malignant blood diseases].

Platelet aggregation with various inductors and platelet secretion were studied in chronic lymphoid leukemia, myeloma, chronic myeloid leukemia and acute leukemia. It was established that disturbed aggregation with adrenaline and disturbed secretion are found more often in these malignant blood diseases. An interesting fact is that there is no correlation between the disturbed platelet functions in vitro and the clinical manifestations of disturbed hemostasis (hemorrhages or thrombosis).

Acute Disease↗
PubMed1983

[Functional criteria for differentiating blast cells in acute leukemia].

Eighty nine patients were examined that had various clinical-morphological forms of acute leukosis, the phagocytic activity of leukosis cells being determined and the synthesis and secretion of lysozyme by them followed up, reflected in its serum level. Leukosis cells of monoblast type were established to have the ability to ingest staphylococci, candida and particles of latex, as well as to synthesize lysozyme, confirmed by the highly elevated enzyme quantity in the sera of the patients. Those functional manifestations are proposed to be used as additional criteria in the determination of cellular type of leukosis proliferation.

Acute Disease↗
PubMed1979

Comparative ultrastructural morphometrical studies in acute leukemia.

Four hundred paramyeloblasts (from meyloblastic, promyelocytic, monoblastic and lymphoblastic types), isolated from peripheral blood of untreated leukemia patients, were studied by planimetric ultrastructural morphometry. The data of 19 parameters for these four paramyeloblastic types were compared with statistical methods. More central "scattered" heterochromatin was found from this morphometric investigation, i.e. early prophases in the lymphoblastic type of acute leukemia (these cases are more sensitive to therapy). The absolute mean values of the areas of whole cells, areas of the nucleus and nucleolus, areas of the heterochromatin and other indices show that different cell clones will undergo leukaemic transformation.

Cytological Techniques↗
PubMed1978

[Ultrastructural studies of the plasma cells in multiple myeloma].

Electron microscopic investigations of 38 patients with multiple plasmocytoma were carried out, the patients being divided into three groups according to the type of monoclonic immunoglobin in serum or urine. Light to moderate cellular-cytoplasmatic asynchronism was found as well as hypertrophic nucleoli and versatile changes in cytoplasmatic organelles of the poliferous plasmocytes. Cellular-cytoplasmatic asynchronism is discussed as a characteristic sign of neoplastic plasmatic cells. No correlation was found between the morphological changes in the nuclei and cytoplasma and the immunoglobin class, secreted from the cells.

Bone Marrow↗
PubMed1978

[Clinical and laboratory aspects of multiple plasmacytoma].

Clinical-laboratory observations were carried out on 40 patients with multiple plasmocytoma. Morbidity maximum was established to be during the fifth and sixth decade of life and that males are more frequently affected and bone manifestations are dominating initial symptoms. The anemic syndrome, the renal syndrome, erythrocyte sedimentation reaction and the data of the differential leukocyte count are discussed in details. Special attention is paid to the pathognomonic examinations in making the diagnosis: myelogram, electrophoresis and immunoelectrophoresis and bone roentgenography. The absence of changes in one of those examinations is concluded not to exclude the diagnosis multiple plasmocytoma as it is found in 10--20 per cent of the cases.

Adult↗
PubMed1977

Comparative ultrastructural morphometric studies of micromyeloblastoid and lymphoblastoid paramyeloblasts.

One hundred lymphoblastoid and one hundred micromyeloblastoid paramyeloblasts, isolated from peripheral blood of untreated leukaemia patients, were studied by electron microscopic morphometry. Considerable differences are to be found between the micromyeloblastoid and lymphoblastoid paramyeloblasts as regards the size of the nucleolar "apparatus", both in the absolute average values and in the index showing the ratio of the nucleolous of the remaining nuclear surface (4.76% for myeloblastoid and 9.96% for lymphoblastoid paramyeloblasts). The central heterochromatin (scattered), which is discussed to be essential for the detection of an early prophase, was found in 3% of the myeloblastoid cells and in 14% of lymphoblastoid ones. The effect of cytostatic therapy is discussed by taking these data into consideration.

Cell Nucleolus↗
PubMed1974

[Pathologic neutrophilia in acute leukemia].

The morphological hemogram peculiarities are described in 10 patients with acute leukosis (nine with myeloblastoid variance and one with monocytoid variance of acute leukosis). Leukemic hiatus is not to be found in all the patients and besides paramyeloblasts--granular "filamented neutrophils" are present in the peripheral blood in considerable absolute values. Cytomorphologic, cytochemical and electron microscopic investigations were carried out on those "paraneutophils". Complex data for pathological leukosis characteristics of those cells were established that differed them from the normal cells. In five of the patients--definite data for acute leukosis were obtained with the histomorphological investigation of the blood tissue, in that way excluding primary myeloblast phase of myeloleukosis. Conclusions were drawn that those cells ("paraneutrophils") have the same prognostic value in peripheral blood as paramyeloblasts and are not affected by polychemical therapy. This was stressed to be a more particular variance of acute leukosis.

Adult↗