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Biomedical subjects

A Dotti

Publications and source records attributed to A Dotti.

26 records · Page 2Linked to original sources
PubMedDate not supplied

Determination of serum angiotensin-converting enzyme in sarcoidosis.

Serum angiotensin-converting enzyme activity was measured in 72 patients with sarcoidosis and in 50 normal controls by a radiochemical assay. SACE levels were examined with respect to the 'activity' of the disease, based on clinical, radiographic and physiological assessment. SACE activity in 34 patients with clinical sarcoidosis (147 +/- 44.3 nmol/min/ml) was significantly high (p less than 0.001) when compared to that of 38 patients who had recovered from sarcoidosis (113.9 +/- 26.4 nmol/min/ml) and 50 normal subjects (97.8 +/- 21 nmol/min/ml). SACE levels were significantly different (p less than 0.01) between 15 subjects with 'active' disease (173.9 +/- 51.9 nmol/min/ml) and those with 'inactive' disease (126.1 +/- 26.3 nmol/min/ml). It is concluded that there is a strict correlation between SACE levels and 'activity' of sarcoidosis if multiple criteria (clinical, radiographic and physiological) are employed.

Adult↗
PubMedDate not supplied

Hexamethyidisiloxane: A 13-week subchronic whole-body vapor inhalation toxicity study in Fischer 344 rats.

Hexamethyldisiloxane (HMDS) is a volatile linear siloxane dimer used in many applications, including precision cleaning, active ingredient carrier, and as a manufacturing intermediate. The purpose of this study was to characterize the subchronic vapor inhalation toxicity of the material as part of a comprehensive toxicology program. Groups of 20 male and 20 female Fischer 344 (F344) rats were exposed to nominal (and mean actual) vapor concentrations of 0, 50 (50), 200 (194), 600 (593), 1,500 (1,509) and 5,000 (5,012) ppm of HMDS, 6 hours per day, 5 days per week, for 13 weeks. No treatment-related signs of clinical toxicity or mortality, statistically significant effects upon body weight gain or food consumption, ophthalmoscopic changes, gross macroscopic necropsy findings, or organ weight changes were noted. Minor hematological, clinical biochemical, and urinalysis changes were seen but were not considered to be of toxicological relevance. Histological lesions in the kidney apparently consistent with male rat-specific alpha-2-urinary globulin nephropathy were observed in male rats exposed to 593, 1,509, and 5,012 ppm of HMDS, accompanied by slightly increased plasma urea and creatinine concentrations. No other treatment-related histological changes were seen in HMDS-exposed rats.

Administration, Inhalation↗