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Biomedical subjects

A Durko

Publications and source records attributed to A Durko.

At least 19 recordsLinked to original sources

[Feverfew as a prophylactic treatment of migraine].

Feverfew has been used in traditional medicine in the treatment of migraine for a long time. In 1985 E.S. Johnson et al. and later J.J. Murphy et al., 1988 and B.K. Vogler et al., 1994 published positive results of prophylactic use of this herb in migraine. Since 1994 through 1996 we studied in our Centre of Migraine Therapy the efficacy of feverfew in migraine treatment. We had 24 patients (women 19-61 years old) in our group. The drug was administered once daily (5 ml of the sap) for 30-60 days. We observed significant reduction of Migraine Index in 8 patients, less significant in additional 5. Our results confirm that feverfew may be beneficial in migraine prophylaxis as an additive drug. Further controlled studies need to be done, especially to establish the optimal dose of the drug.

Adolescent↗

[Studies of heart rhythm variability in migraine. Preliminary communication].

Spectral analysis of hart rhythm variability makes possible assessment of the state (power) of autonomic innervation of the heart. The reported study was carried out in 40 patients (22 women) with migraine. The studies were done in times between migraine attacks. The control group comprised 62 clinically healthy subjects. In most patients (over 61%) the sympathetic and parasympathetic innervation of the heart was weaker than in healthy subjects and the index of automatic equilibrium in the sinus node was lower than in controls.

Adult↗

[So-called cervicogenic headache].

After a description of the clinical pattern of the newly isolated by Sjaastad et al. from of headaches, that is cervicogenic headache the authors report two own cases in women aged 37 and 57 years. The cases agreed completely with the description of Sjaastad et al. and other authors, and they enrich the number of case reports on this disease.

Adult↗

Suloctidil therapy in migraine: an open pilot study.

An open pilot study was carried out in 27 patients with severe and frequent migraine attacks who had failed to respond adequately to other drug therapy, to assess the effectiveness and tolerance of prophylactic treatment with suloctidil. Patients received 600 mg suloctidil daily for 6 weeks. Response, assessed on the reduction in frequency of attacks, was considered as good in 7 patients and as significant improvement in 11 patients. Treatment was rated as of doubtful value or as ineffective in the other 9 patients. One patient stopped treatment because of adverse reactions and 10 others reported mild side-effects.

Adult↗

[Treatment of functional disorders of the masticatory system in patients with headaches].

In 114 cases of spontaneous headaches treated at the Migraine Centre at the Department of Neurology, Medical Academy in Lódź, various types of stomatognathic system dysfunctions were found, and 24 were qualified for stomatological treatment of these dysfunctions. The treatment was causative and included rehabilitation of the stomatognathic system and denture reconstruction. This treatment gave particularly good results in atypical pains in the face and head. Less good effects were obtained in chronic tension headaches and mixed headaches. The discussed method gave no improvement in migraine and cluster headaches.

Adult↗

[Evaluation of the status of the stomatognathic system in patients with idiopathic headaches].

The stomatognathic system was assessed in 114 subjects with various types of idiopathic headaches. Stomatognathic system dysfunctions were recognized most frequently in patients with atypical facial pain and headache, and with mixed headache. Much less frequently these dysfunctions were present in patients with migraine or cluster headaches. The obtained results suggest that stomatognathic system dysfunctions should be considered in the pathogenesis of certain headaches.

Chronic Disease↗

[Analysis of clinical and electroencephalographic findings in common vasomotor headache].

The authors analysed the clinical pattern of manifestations and electroencephalographic findings in 120 patients with vasomotor headache, who were attending the Migraine Treatment Centre at the Department of Neurology, Medical Academy in Lódź. During 5 years of observation these patients accounted for 20% of all cases of idiopathic headaches treated in this Centre. It was observed that the clinical manifestations and electroencephalographic findings in vasomotor headaches were non-characteristic. The diagnosis of this headache must be reached after ruling out all other idiopathic and symptomatic headaches.

Adolescent↗

[Bilateral occurrence of symptoms of Horton's headache (cluster headache)].

The authors discuss the problem of bilateral occurrence of symptoms in cluster headache. Literature survey shows that bilateral headache were observed in 10-13% of cases by various authors. In own material of 63 cases the authors found bilateral symptoms in 9.5% of cases and describe in more detail two cases. An own classification of bilateral cluster headaches in suggested.

Adult↗

[Analysis of electroencephalographic findings in patients with Horton's headache].

The authors analysed electroencephalographic findings in 36 patients with Horton's headache (cluster headaches). It was found that EEG findings in Horton's headache are usually normal and show considerable stability. Slight EEG changes observed in a low number of cases were usually similar to those observed in the general population. The analysis of bioelectric activity of the brain in patients with this headache suggests an extracerebral mechanism of this disease.

Action Potentials↗

[Current views on pathophysiology of migraine. Part III: Biochemical hypothesis. The role of blood platelets].

Systematic studies on the biochemistry of migraine were first undertaken in early 1960s; they initially concerned serotonin metabolism. The studies were next extended, covering catecholamines, histamine, free fatty acids, selected peptides and hormones. The results were mostly disappointing and such studies were mostly given up. In the last years we have been witnessing the come back of the study on the role of serotonin in migraine as the neurotransmitter involved in the antinociception and vascular innervation. In the 1970s a great deal of studies on blood platelets as serotonin reservoir were undertaken in migraine patients.

Brain↗