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Biomedical subjects

A Dwarakanathan

Publications and source records attributed to A Dwarakanathan.

5 recordsLinked to original sources
PubMed1987

Hypercalcemia of sarcoidosis treated with cellulose sodium phosphate.

A patient with pulmonary sarcoidosis and symptomatic hypercalcemia had elevated serum 1,25-dihydroxyvitamin D and angiotensin-converting enzyme levels, with evidence of deterioration of renal function. Pulmonary function tests were normal and there were no other findings to warrant immediate steroid use. She was treated with cellulose sodium phosphate, in an effort to control the hypercalcemia. Serum calcium declined to normal values within 4 weeks and was associated with symptomatic improvement and normalization of BUN and creatinine, indicating perhaps a direct relationship between serum calcium and renal function in this setting. These observations suggest that the hypercalcemia of sarcoidosis may be successfully treated with cellulose sodium phosphate presumably by reducing intestinal calcium absorption, but further clinical trials will be necessary to establish its effectiveness in the long term.

Blood Urea Nitrogen↗
PubMed1976

Dissociation between TSH and prolactin dynamics in treated thyrotoxicosis.

TSH and prolactin secretory patterns in thyroid disease have generally been reported as concordant. We studied TSH and prolactin responses to TRH infusion (500 mug) in euthyroid individuals previously treated for thyrotoxicosis with 131I or antithyroid drugs. The 131I-treated group (seven men, twenty women) had been clinically and biochemically euthyroid (normal serum thyroxine and triiodothyronine levels) for 6 months to 4-5 years (kappa +/- SD = 17-1 +/- 4-1 months). Based on maximal TSH increment (deltaTSH), three patient groups were identified: Group 1 [normal deltaTSH, n = 6]: delta prolactin was normal in two, blunted in one and exaggerated in three. Group 2 (exaggerated TSH response, n = 8): delta prolactin was normal in two, blunted in one and exaggerated in five. Group 3 (TSH nonresponders, n = 13): delta prolactin was normal in five, blunted in three, and exaggerated in five. Eleven patients (three men, eight women) were studied after 6 months antithyroid-drug treatment. All were clinically and biochemically euthyroid. All but one showed a blunted TRH-TSH response. All three men showed an exaggerated delta prolactin as did four of eight women. Three women showed a blunted delta prolactin and in one, delta prolactin was normal. Thus, TRH-induced TSH and prolactin response patterns in treated thyrotoxicosis are not uniformly concordant, and, while a blunted or absent TSH response commonly persists long after euthyroidism has been restored, this is most frequently accompanied by a normal or exaggerated prolactin response.

Adult↗
PubMed1975

Marked elevation of plasma renin activity during post diuretic sodium conservation in furosemide stimulated subjects.

Plasma renin activity (PRA) was measured in 3 subjects during control period, after 3 days of oral furosemide (40 mg B.I.D.) and on the 2nd, 3rd and 5th days post diuresis. PRA, ng of angiotensin per ml plasma per 3-hour incubation was 8, 0.4 ng during the control period and rose to 51, 6 and 16 respectively. During the post diuretic phase, PRA rose to 99 in the first and 49 in the second subject. Urinary sodium was drastically reduced during this period. By 5th post diuretic day PRA returned to normal values. Striking elevations of PRA during intense sodium conservation are in accord with a concept of reduced Na load to macula densa stimulating renin release.

Aged↗