Are targeted contrast agents realistically going to reach the clinic? Recent regulatory experience with targeted MRI contrast agents.
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Biomedical subjects
Publications and source records attributed to A Dzik-Jurasz.
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A little over 30 years ago, Sir Godfrey Hounsfield and his colleagues revolutionized medical imaging by developing CT scanning. In recent years a combination of improved technology and a deeper understanding of tumour biology have led to the development of imaging based strategies aimed at interrogating tissue structure and function. The prospects of this new technology include the prediction of tumour response and the non-invasive study of conventionally inaccessible yet important pharmacological compartments. This article explores how functional nuclear MRI and spectroscopy have been used in predicting response to anticancer therapy in rectal cancers and to assess the biliary excretion of chemotherapeutics.
The imaging of angiogenesis in human disease represents an exciting prospect for those involved in the drug development process. With an increasing focus on the therapeutic modulation of angiogenesis in man, the development of technologies capable of monitoring angiogenic drug interventions non-invasively should be welcomed.
Interstitial cystitis is an uncommon disease reported predominantly in females. Recently we were involved in the management of 4 men who had the clinical, endoscopic and pathological features consistent with the diagnosis of interstitial cystitis. The rarity of occurrence of the disease in males prompted us to report these cases.
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