Biomedical subjects

A E Cury

Publications and source records attributed to A E Cury.

4 recordsLinked to original sources

PubMed1997

Interactions between amphotericin B and nitroimidazoles against Candida albicans.

This work proved that nitroimidazole antiprotozoal agents, such as metronidazole, ornidazole, secnidazole and tinidazole, in concentrations of up to 64 micrograms ml-1 did not present any antifungal activity against 17 strains of Candida albicans. The combination of each drug with amphotericin B showed the occurrence of variable interactions according to the studied strain. Promising results were observed based on synergistic and additive interactions of the polyene with the metronidazole; the inhibitory and lethal activities of the drugs were potentiated against all strains in concentrations reachable in vivo.

Amphotericin B↗

PubMed1986

Studies on components of the chloroform-methanol extract from Madurella grisea.

Some of the lipids described in many fungi were found in Madurella grisea, in addition to other diethyl ether-soluble components with peculiar characteristics. One fraction structurally related to ethane diol (ethylene glycol) accounted for about 41% and a compound identified as methyl terephthalate represented about 38% of the extract. No steroids were detected. The absence of these lipids may perhaps explain the resistance of this organism to polyene antibiotics.

Chloroform↗

PubMedDate not supplied

[The sensitivity of yeasts from the Candida genus isolated from cancer patients to polyene antifungals].

Candida strains susceptibility from cancer patients were compared with Candida strains susceptibility from patients, without cancer by MIC (minimal inhibitory concentration) and MFC (minimal fungicidal concentration) to Amphotericin B and Nystatin. Broth dilution method and agar dilution method were the procedure employed. The authors find no significant differences between the studied groups. The problem of Candida resistance to polyene antifungals is discussed.

Amphotericin B↗

PubMedDate not supplied

[A comparative study between broth dilution and agar dilution technics in antibiograms for Candida].

The performance of broth dilution method and agar dilution method were compared by MIC (minimal inhibitory concentration) and MFC (minimal fungicidal concentration) from Candida strains to polyene and imizadole antifungal agents. The concordance between these methods was drug dependent. The best percent of concordance were showed when the polyenes were tested. The problems of sensitivity test for yeasts to antifungal drugs are discussed.

Agar↗