Biomedical subjects
A E Dyson
Publications and source records attributed to A E Dyson.
Congenital hypothyroidism.
This paper presents a case report of congenital hypothyroidism that illustrates some of the issues in screening for this disorder. Congenital hypothyroidism has several causes, the most common of which is thyroid dysgenesis. Most affected infants have no historical clues or physical findings to suggest diagnosis. Neonatal screening combining thyroxine and thyrotropin screening have resulted in increased detection, although false-negatives do occur, and the physician must carefully observe all newborns for the findings of congenital hypothyroidism. Early treatment improves the prognosis considerably. This paper reviews the pathophysiology, diagnosis, and treatment of congenital hypothyroidism.
Group G streptococcal colonization and sepsis in neonates.
Group G streptococci were isolated from the blood of seven neonates over a five-year period at the New York Hospital. All but two were born near term. All presented clinically with signs and symptoms of neonatal sepsis. Only one case was associated with a major complication--epidermolysis bullosa; this patient died. Two presented as late-onset sepsis at 11 and 12 days of age. Six of the seven responded promptly to antibiotic therapy. A one-year survey was carried out of colonization with groups B and G streptococci at the time of discharge (day 3). Colonization with group G streptococci varied between 41 and 76% of babies each month. Group B streptococcal colonization ranged between 1 and 11%. Statistical analysis suggested that colonization with these organisms may be a mutually exclusive phenomenon.