PubMed Health⌕ Search

Biomedical subjects

A E Finkbeiner

Publications and source records attributed to A E Finkbeiner.

At least 19 recordsLinked to original sources
PubMed2006

Efficacy and safety of vardenafil in men with erectile dysfunction caused by spinal cord injury.

OBJECTIVE: To assess the efficacy and tolerability of vardenafil in men with erectile dysfunction (ED) due to traumatic spinal cord injury (SCI). METHODS: In this multicenter, double-blind, placebo-controlled, parallel-group 12-week study, 418 men aged 18 years and older with ED for more than 6 months consequent to SCI were randomized to vardenafil (n = 207) or placebo (n = 211) (10 mg for 4 weeks, then maintained or titrated to 5 or 20 mg at weeks 4 and 8). Efficacy assessments included the erectile function (EF) domain score of the International Index of Erectile Function questionnaire and diary questions regarding penetration, maintenance of erection to completion of intercourse, and ejaculation. RESULTS: Baseline patient characteristics were similar in the vardenafil (mean age 40 years) and placebo (mean age 39 years) groups. Mean baseline EF domain scores were 11.6 in the vardenafil group and 12.1 (moderate ED) in the placebo group. EF domain score in the vardenafil group improved to 22.0 (mild ED) at last observation carried forward vs 13.5 in the placebo group (p < 0.001). Over 12 weeks of treatment, mean per-patient penetration (76% vs 41%), maintenance (59% vs 22%), and ejaculation (19% vs 10%) success rates were significantly greater vs placebo (all p < 0.001). The most frequently reported drug-related adverse events were headache (vardenafil 15%, placebo 4%), flushing (vardenafil 6%, placebo 0%), nasal congestion (vardenafil 5%, placebo 0%), and dyspepsia (vardenafil 4%, placebo 0%). CONCLUSION: Vardenafil significantly improved erectile and ejaculatory function and was generally well tolerated in men with erectile dysfunction due to spinal cord injury.

Adult↗
PubMed1999

In vitro responses of detrusor smooth muscle to stretch and relaxation.

In vitro studies subjecting detrusor smooth muscle to stretch and relaxation support the concept that bladder tonus and accommodation result from physical properties of the bladder wall and are not dependent upon neural activity. The properties of automaticity, hysteresis and length/tension relationships of smooth muscle seen clinically and in vivo are also seen in vitro.

Animals↗
PubMed1998

Clinical experience with the Storz Modulith SL 20 lithotriptor.

BACKGROUND: A Food and Drug Administration pre-market approval study evaluated the safety and effectiveness of the Storz Modulith SL 20 lithotriptor. METHODS: Protocol was a maximum of 2,000 shock waves per treatment and no more than three treatments per patient. Safety and effectiveness parameters were defined and followed. RESULTS: The overall success rate was 74.6% with a stone-free rate of 63.6%. No clinically or statistically significant adverse trends were noted acutely or in follow-up. CONCLUSIONS: The Storz Modulith SL 20 lithotriptor is a safe and effective device to treat renal and ureteral calculi in an outpatient setting using intravenous sedation/analgesia.

Adult↗
PubMed1992

Differentiation of human prostate cancer from benign hypertrophy by in vitro 1H NMR.

In vitro 1H NMR spectra were acquired for perchloric acid extracts of tissue samples of human prostate. Seven patients were diagnosed with prostate cancer, 13 with benign prostatic hypertrophy, and 3 with both conditions. Statistically significant differences between the cancer and benign groups were seen for the metabolite peak area ratios of citrate, creatine, and phosphorylcholine to alanine, and citrate to glutamate. There was no correlation of Gleason grade with any of the ratios measured for the cancer samples. Spectra from different sections of large tumors often yielded substantially different area ratios, confirming the heterogeneous nature of these prostate tumors.

Alanine↗
PubMed1991

Postoperative urinary retention associated with total hip and total knee arthroplasties.

Urinary retention following total hip and knee arthroplasty is a common problem frequently necessitating either prolonged urethral catheter drainage or intermittent catheterization. The direct relationship of urinary tract instrumentations, procedures, and infections to deep sepsis in total hip replacements is well documented. Pharmacologic therapy to stimulate voiding or augment bladder emptying is thus theoretically preferable to the use of catheterization. Prasozin hydrochloride, an alpha blocker, relaxes the smooth musculature of the posterior urethra and prostrate and has been used to treat urinary obstruction secondary to benign prostatic hypertrophy. A prospective study in 60 male patients showed a statistically significant decrease in postoperative urinary retention with the perioperative administration of prazosin (p less than 0.01). A higher incidence of urinary tract infection was seen in patients who developed urinary retention (3% versus 20%) (p less than 0.01). Uroflowmetry parameters were not predictive of the patient at risk for retention and were unaltered with the administration of prazosin. Prazosin can be an effective adjunct in the prophylaxis of postoperative urinary tract infections and may decrease the potential risk for total joint sepsis.

Aged↗
PubMed1990

Urinary incontinence volume measurement in elderly male inpatients.

Urinary incontinence is a debilitating disease in the elderly and is a leading cause of nursing home placement for aged patients in our society. Accurate measurement of urinary incontinence in elderly inpatients is necessary to determine the severity of the disease and to evaluate the efficacy of any treatment methods being investigated. The technique required for evaluation of elderly chronic care inpatients is different from methods that can be used in patients who do not have the ambulatory and cortical impairment that is common among chronic care inpatients. Since chronic care nursing staff involvement is necessary for accurate measurement and recording of incontinence episodes, a procedure for measurement must be well defined and clearly outlined in a sequence that can be followed easily. This study provides a method of incontinence volume assessment for elderly inpatients that can be performed by inpatient nursing staff to provide accurate incontinence volume measurements. Quantitative urinary incontinence volume measurements were done over ten days in 42 elderly men. Urinary incontinence presented as a significant problem in these patients over a wide range of both frequency and volume of urinary incontinence episodes. The volume measurement technique described allowed the nursing staff to identify, measure, and record incontinence severity over a wide range of frequency and volume while monitoring multiple patients simultaneously.

Aged↗
PubMed1990

Responses of detrusor smooth muscle to stretch and relaxation: in vitro study.

An in vitro model subjecting bladder muscle strips to continuous stretch relaxation evaluated-the properties of passive muscle length and tension. Tension generated as a strip was stretched or relaxed was found to be stretch-rate dependent. The primary influence of stretch rate on muscle tension is by alteration of muscle length; however, stretch and relaxation rates do influence the inherent smooth muscle properties of hysteresis, stress-relaxation, and adaptation. The characteristic filling curve to the point of bladder contraction seen clinically during cystometry in the neurologically intact subject can be reproduced in isolated bladder muscle strips. The bladder function of storage is a result of passive smooth muscle properties of muscle length and tension which can, however, be altered by superimposed neurologic influences.

Adaptation, Physiological↗
PubMed1988

Urologic manifestations of drug therapy.

Numerous drugs used for a variety of medical conditions may be involved in urologic disease or dysfunction. Manifestations include sexual dysfunction, voiding disturbances, incontinence, renal impairment, urolithiasis, obstructive uropathy, urothelial tumors, and others. The office urologist thus must be aware of the possibilities, which are listed and discussed briefly.

Drug-Related Side Effects and Adverse Reactions↗
PubMed1987

Loin pain hematuria syndrome.

Loin pain hematuria syndrome occurs primarily in young women and is manifested by recurrent loin pain, hematuria, and abnormal renal vasculature. This syndrome was first described in 1967 by Little in the British literature. Since that time, approximately 60 cases have been reported. In this paper, we describe a case and provide a pertinent review of the literature concerning diagnosis and treatment.

Adult↗
PubMed1983

In vitro effects of vasoactive intestinal polypeptide on guinea pig urinary bladder.

Vasoactive intestinal polypeptide (VIP) may have a neuronal function regulating smooth muscle activity. At concentrations ranging from 0.25 to 3.0 micrograms/ml VIP elicited no significant changes in baseline tension, magnitude, or frequency of contractions of guinea pig bladder muscle strips. Likewise, VIP did not inhibit significantly the rise in baseline tension elicited by acetylcholine or electrical stimulation.

Acetylcholine↗
PubMed1981

In vitro effects of prostaglandins on the guinea pig detrusor and bladder outlet.

The effects of prostaglandins on the urinary bladder and urethra were determined using guinea pig detrusor and urethral muscle strips in an in vitro muscle bath. Prostaglandins E1, E2, F1a and F2a caused contraction of detrusor strips and relaxation of strips from the bladder outlet. Their mechanism of action appears to be mediated through the sympathetic nervous system in both the detrusor and outlet with some direct relaxation effects in the outlet.

Animals↗
PubMed1980

Concept of pharmacodynamics of urinary storage and micturition.

The exact neuropharmacologic sequences governing continence and micturition are not yet known. Based on current investigations and those previously conducted, a concept of the anatomic, physiologic, and neuropharmacologic factors governing continence and micturition is presented.

Humans↗