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Biomedical subjects

A E Hogan

Publications and source records attributed to A E Hogan.

6 recordsLinked to original sources
PubMed1994

The role of bacterial antigen detection tests in the diagnosis of bacterial meningitis.

We sought to determine the circumstances under which cerebrospinal fluid (CSF) bacterial antigen detection tests. (BADT) are indicated. The medical records of 146 consecutive patients with bacterial meningitis seen from 1986 to 1991 were reviewed retrospectively (mean age 16 months; median eight months). Bacterial meningitis was defined as a positive CSF culture or a positive CSF BADT, in association with the clinical presentation and response to antibiotic treatment consistent with bacterial meningitis. Before lumbar puncture, 61/146 (42%) of meningitis patients had received treatment with antibiotics. CSF BADT was performed on 56/61 (92%) of pretreated patients; of these, 48 (87%) were positive, and 8 (13%) were negative. In this group, 15/61 (25%) of pretreated patients had a negative CSF culture but a positive CSF BADT. All 85 patients who did not receive antibiotics before lumbar puncture had positive CSF cultures and 52/75 (69%) had positive CSF BADT. Because prior antibiotic therapy may impair bacterial growth from the CSF, a CSF BADT should be performed whenever the patient has received prior antibiotic treatment.

Adolescent↗
PubMed1990

Transcutaneous oxygen tension in preterm neonates during neonatal behavioral assessments and heelsticks.

This study evaluates the effects of neonatal behavioral assessments and heelsticks on transcutaneous oxygen tension (TcPO2) in 37 preterm neonates from a neonatal intensive care unit. Two behavioral assessments were evaluated, the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) and the Neurobehavioral Assessment for Preterm Infants (NAPI). TcPO2 during heelsticks was used as a comparison because reliable decreases have typically been noted during heelsticks. Although the heelsticks resulted in significant declines in TcPO2, the behavioral assessments led to only negligible changes in TcPO2. Observed changes during the behavioral assessments occurred in a small number of infants, primarily during the few test procedures administered to the infants outside of their isolettes. Accordingly, it is suggested that time outside the isolette and associated temperature changes may be more critical variables than the assessments per se.

Arousal↗
PubMed1989

Early assessment of sensorimotor and cognitive development in high-risk infants.

Assessed 88 infants at risk for mental retardation on the Bayley Scales of Infant Development and a measure of visual recognition memory at 3 months corrected age. Bayley scales were administered again when the infants were 1-year-old. At 3 months of age the Bayley scales and the measure of visual recognition memory were not significantly correlated. Both measures, however, showed significant correlation to the Bayley scales administered at 1 year of age. Results from regression analyses indicated that each measure at 3 months of age was related to a different source of variance in the 1-year measure. These results are consistent with the hypothesis that at 3 months of age the visual recognition memory measure is a better early window into later cognitive development than the Bayley scales.

Child Development↗
PubMed1979

A comparison of urinary specific gravity and osmolality in sheep.

Urinary specific gravity and osmolality were determined on urine samples collected from three categories of sheep -- animals that were normal, in diuresis or had nephron numbers reduced surgically. Values for specific gravity and osmolality were compared and regression coefficients calculated for each category of sheep. In this study, specific gravity was found to be a relatively reliable indicator of osmolality, the correlation being highest in the urine from the sheep with reduced nephron numbers.

Animals↗