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Biomedical subjects

A E Kessell

Publications and source records attributed to A E Kessell.

3 recordsLinked to original sources

Cervical hyperaesthesia in a Maltese Terrier with necrotising meningoencephalitis.

A 15-month-old female neutered Maltese Terrier was presented with a 12 hour history of low head carriage, reluctance to move and yelping when picked up. Physical examination was unremarkable apart from cervical hyperaesthesia. Twenty four hours after initial assessment there was significant clinical deterioration, with the dog exhibiting lateral cervical flexion and neurological abnormalities consistent with diffuse multifocal cerebral dysfunction. Cerebrospinal fluid analysis revealed a marked pleocytosis. Euthanasia was elected and gross necropsy findings included swelling of the right frontal cortex and a focal area of necrosis in the ventrolateral grey matter of the frontal cortex. Histological examination of the brain tissue revealed focal areas of necrosis and generalised non-suppurative inflammation consistent with a morphological diagnosis of necrotising encephalomyelitis.

Animals↗

Squamous cell carcinoma with sarcomatous stroma in the nasal cavity of a dog.

This is a report of an unusual squamous cell carcinoma in the nasal cavity of a dog. A 13-year-old Golden Retriever was presented with a unilateral nasal and ocular discharge. Although a nasal tumour was suspected, initial diagnostic investigations were unrewarding, and, with worsening clinical signs, the dog was euthanatized. Necropsy examination confirmed the presence of a nasal tumour that was composed histologically of both a well-differentiated squamous cell carcinoma component blending with a predominant spindle cell component. Immunohistochemical staining with anti-human keratin/cytokeratin (AE1/AE3, CAM 5.2 and broad spectrum cytokeratin), Vimentin, Desmin, smooth muscle actin and S-100 protein supported a diagnosis of a squamous cell carcinoma with (pseudo) sarcomatous stroma.

Animals↗