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Biomedical subjects

A E Kramer

Publications and source records attributed to A E Kramer.

10 recordsLinked to original sources

Trends in future urodynamics: computer support-data base-digitized imaging.

The use of computers in urodynamics must be based preferably on the structure of the urodynamic investigation itself. This enables implementation of computerized systems in the urodynamic laboratory in the most natural way and provides transparency of urodynamic software for the investigators. Additionally, the algorithms of the urodynamic software then can provide for a urodynamic investigation following a logical path based on the patient's history and clinical data and (automatically interpreted) results from earlier steps in the urodynamics. As an extension of this structured logical reasoning, the computer use in urodynamics can be extended to include validation and decision rules, comprising measurement data and rules for interpretation and combination of history, clinical and measurement data. Conclusions will be presented then in the form of a preliminary differential diagnosis, including the odds for each of the possible diagnoses. These kinds of computerized interpretation systems will be validated by comparison with the classical clinical diagnoses and are generally known as expert systems. These systems rely on logical branching-as opposed to systems that are statistical in nature and use large data bases to classify individual data into known groups. Data bases will remain for the purpose of documentation, based on individual patients and comprising all patient data-comparable to the existing patient files in the hospital's archives. The computer files have to include also the original data from functional studies like urodynamics-and not just the abstracted conclusions-and from imaging techniques. Intelligent compression of data prevents the data bases from exploding. Digital imaging techniques combined with computerized urodynamic investigations open possibilities for dynamic analysis of morphologic data and combination thereof with urodynamic measurement data.

Databases, Factual

Entering data into expert system for lower urinary tract pressure-flow studies.

This paper describes methods of entering data into an expert system used to study lower urinary tract pressure and flow. Data is usually entered into an expert system directly from the keyboard or on an online basis. We have developed a new method of offline data entry using a photoscanner. For this method, we developed versatile software to convert the graphic data read by a photoscanner to online data format. This software allows us to handle graphic data printed on paper in the same way as online data. The software is also designed to solve the problems caused by blurred lines or ink spots on printed charts. In other words, the software compensates for data reading errors caused by blurred or stained lines on printed charts. Because data can be entered through the photoscanner, the enormous volume of data already recorded in graphic forms can be used by the expert system. As a result, the diagnostic capability of the expert system is significantly improved.

Diagnosis, Computer-Assisted

Recurrence of superficial bladder carcinoma after intravesical instillation of mitomycin-C. Comparison of exposure times.

A total of 70 patients were treated with intravesical instillations of Mitomycin-C (MMC) following transurethral resection for superficial bladder carcinoma. In this randomised prospective study the influence of 2 exposure times (0.5 and 1 h) was studied in relation to tumour recurrence, recurrence interval, tumour progression and toxicity. The number of patients with recurrent tumours was significantly lower in the 1-h group. Tumour progression was seen in only 2 patients in each group and all had primary or secondary carcinoma in situ of the bladder or prostatic urethra. Fourteen patients were excluded from further evaluation because of side effects. A longer instillation time over a longer period and a lower dose of MMC are recommended.

Administration, Intravesical