Biomedical subjects
A E MacKinnon
Publications and source records attributed to A E MacKinnon.
In vitro colonisation of cerebrospinal fluid shunts.
A reliable method of colonizing cerebrospinal fluid shunts has been developed in vitro. A simulated cerebrospinal fluid is described in which the test organism (Staphylococcus epidermidis) multiplied. All experiments were conducted in a CO2 enriched atmosphere.
Possible prevention and eradication of cerebrospinal fluid shunt infection with povidone iodine in vitro.
The results of preliminary in vitro studies of the efficacy of povidone iodine (P.V.I.) in preventing and eradicating infection in cerebrospinal fluid shunts are reported. After preliminary flushing of the system with P.V.I., it was not found possible to colonize valves. To eradicate infection from a previously colonised shunt it was found necessary to inject P.V.I. three times at 24 hourly intervals at a point above the level of colonisation.
Strangulated umbilical hernia in a child.
We describe a case of strangulated umbilical hernia in a girl aged 5 years. She presented with an acute inflammatory lesion at the umbilicus which was initially thought to be due to cellulitis with possible abscess formation. Exploration revealed an umbilical hernia containing necrotic greater omentum.
Intravenous urography and childhood trauma.
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Assessment of CSF shunts by Doppler ultrasound.
Doppler ultrasound was used to detect flow through 160 C.S.F. shunt systems, 94 without suspected blockage, 62 with suspected blockage. An accuracy of 87% was achieved and we found this test helpful in clinical management in a significant number of cases. The test can distinguish between blockage of proximal and distal catheters and in certain situations can indicate infection of the distal catheter. Follow-up is continuing to determine the reliability of this technique in deciding whether asymptomatic patients are valve-dependent or not. The test is simple to learn and noninvasive.
Computers and urinary tract infection.
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Lateral meningocele and defect of abdominal wall.
A case of lateral meningocele associated with deficiency of the thoraco-abdominal wall is reported. It is suggested that both of these defects are due to interference with the development of the paraxial mesoderm by a single injury.
Metronidazole-resistant Bacteroides from untreated patient.
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Skin closure with polyglycolic acid (Dexon).
Cosmetically satisfactory scars were achieved in 94.5% of skin crease orchidopexy wounds sutured with subcuticular polyglycolic acid. Of twenty-seven similar wounds closed with interrupted black silk sutures 18.5% developed hypertrophy at the medial end.
Total intestinal aganglionosis. An autosomal recessive condition?
A case of total intestinal aganglionosis in a sib of a previously recorded patient is presented. The number of cases now reported is 9 in six families. The possibility that this condition is a distinct entity inherited in an autosomal recessive manner is discussed.
Active treatment of ganglia in children.
One hundred and twenty-eight children, admitted for active treatment of ganglia around the wrist, hand, ankle or foot are reviewed. The methods of treatment are discussed. The most satisfactory results were obtained by excision (7-2% recurrence) and incision with a tenotome (11% recurrence). The overall recurrence rate was 19%. The ganglia around the wrist had the highest rate of recurrence.
Pseudomonas osteomyelitis following puncture wounds.
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Sarcoma after injection of intramuscular iron.
Two cases are presented of sarcomata arising at the site of previous iron dextran injections. One of the tumours showed a histological pattern associated with iron dextran administration in animal experiments.
A simple technique for temporary suprapubic catheterization.
Temporary suprapubic catheterization is frequently required, often in emergency situations. We describe a simple technique employing a 14 G intravenous cannula and 4 FG feeding tube. The principle can be applied to children and adults.
[A anti-siphon device in the treatment of excessive cerebrospinal fluid drainage in patients with ventriculoatrial and ventriculoperitoneal shunting valves].
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[The anti-siphon mechanism in the treatment of excessive cerebrospinal fluid drainage in patients with ventriculoatrial and ventriculoperitoneal shunting valves].
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