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Biomedical subjects

A E Marble

Publications and source records attributed to A E Marble.

At least 55 records · Page 3Linked to original sources
PubMed1980

Does vascular steal occur following femorofemoral bypass grafting?

Vascular steal has been reported following aortoiliac and crossover femoral vascular reconstruction. Although the steal phenomenon has been described in clinical situations some have denied its existence. The authors attempted to determine whether or not vascular steal occurs after femorofemoral bypass operation. Fifteen adult mongrel dogs underwent femorofemoral bypass grafting. Stenosis of the iliac artery was simulated with a specially designed device. Blood flow was measured with the femoral graft open and closed in combination with superficial femoral and deep femoral artery obstruction in the donor and recipient circulations. There was no statistically significant decrease in flow to the donor leg in any situation. Thus the authors conclude that vascular steal does not occur following femorofemoral bypass operation.

Animals↗
PubMed1979

Hepatic blood flow and metabolism.

The relationship between liver blood flow and hepatic metabolism remains unclear. An animal model as well as a methodology that permits simultaneous assessment of both of these functions are proposed. Several fractions of inspired oxygen were used to produce arterial oxygen levels commonly seen in clinical practice; these ranged from hyperoxemia to established hypoxemia. Over this range there were no considerable changes in transhepatic blood flow, but there were considerable changes in hepatic metabolism as shown by measurements of the hepatic parenchymal pH, transhepatic oxygen consumption, and lactic acid use. Of these, the parenchymal pH seems to be the most sensitive indicator of metabolic events.

Animals↗
PubMed1978

Assessment of the isolated right atrium as a pump.

The ability of the hemodynamically isolated dog right atrium to pump against a resistance equivalent to normal pulmonary artery pressure was tested in an in vivo preparation. At a preload of 10 mm. Hg, the right atrium reached a peak systolic pressure of 18.2 mm. Hg (+/- 1.3 S.E.M.) against an afterload of 12 mm. Hg, but it could eject a flow only equivalent to 53 percent (+/-6) of the dog's cardiac output (n = 6). At a preload of 15 mm. Hg, a peak systolic pressure of 21.5 mm. Hg (+/- 0.8) was recorded against an afterload of 17 mm. Hg, but again, only 55 percent +/-5) of the dog's cardiac output was ejected. It appears that the cardiac output from the nonhypertrophied right atrium is limited by the strength of the right atrial contraction and the physiological limits imposed by the venous driving pressure.

Animals↗
PubMed1975

Correlation between hemodynamic changes and the presence, size, and site of myocardial infarction.

Values for eight measured and calculated hemodynamic variables were recorded in 12 dogs before and after experimental anterior myocardial infarction. Changes were noted in stroke work and stroke power only; the changes in stroke work and stroke power were closely correlated with the presence of the infarct, whereas the changes in the other six dynamic variables were unpredictable and uncorrelated. The degree of correlation between the stroke work and power, and the size and site of the infarction, however, suggested that none of the eight variables would be an adequate indicator of all three characteristics of the infarction.

Animals↗