[Effects of neo-kyotorphin and delta sleep-inducing peptide on the rectal temperature in rats in the norm, during hypothermia and self-warming].
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Animals↗
Biomedical subjects
A E Matsionis
Publications and source records attributed to A E Matsionis.
[Recombinations of neocortex ultrastructure in hibernating animals during adaptation to hypothermia].
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Animals↗
[Stomach and duodenal ulcer in endocrine tumors].
Clinico-anatomical analysis was performed in 13 cases of endocrine tumors of various sites with concomitant gastric and duodenal ulcer (Zollinger-Ellison's syndrome). Ulcer tended to recur in these patients; it was associated with pronounced pain and involved a high rate of such complications as perforation, bleeding and gastrointestinal fistula. Endocrine tumors were found to locate in the pancreas (5) and duodenum (5) while, in the other three patients, multiple endocrine adenomatosis (type 1) was identified. Correct diagnosis was made in three cases only and surgery was successful in two of them. Errors are analysed.
Adult↗
Delta-sleep-inducing peptide as a modulator of the ultrastructure of synapses.
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Animals↗
[Current status and trends in the development of medical information systems for morphological research].
The time of cooperative action of the information medical systems is coming. Standardization of clinical laboratory information systems is one of the most difficult but important problems for clinical laboratory community and technicians. Electronic data exchange requires agreement on the data element format by which healthcare institutions can exchange. Computerization of health care service raises the problem of security because the risk of violation of medical privacy is dramatically increasing. Unauthorized users can access, copy, alter, delete or distort hundreds or thousands of medical records within minutes. Information can be faulted by individuals or system failure. It is necessary to discuss and make a final decision of joining some standard for the purpose of integration.
Delivery of Health Care↗
[Clinical significance of histological types of prostatic cancer].
Biopsy material obtained from 310 patients with prostatic cancer (PC) was used in the study of the incidence rate of different PC histological types, of tumor cell immunophenotype and differentiation by Glison. The results of the study have shown that definition of the tumor histological type and tumor immunophenotype facilitates identification of tumors with the most malignant potential. Therefore, this definition should be included into the diagnostic complex in the study of PC. Choice of treatment policy should not be based only on differentiation of the tumor process by Glison. The decision should be made only after establishment of histogenesis and immunophenotype of tumor cells. The presence of neuroendocrine differentiation is an unfavourable prognostic factor.
Adenocarcinoma↗
[Kidney carcinosarcoma].
A kidney tumour in a 36 year old female is described. The tumor was soft, of gray-brown color, size 12 x 11 cm. Histological, immunohistochemical and ultrastructural findings have demonstrated the signs of biphasic epithelial and mesenchymal cell differentiation. These data allowed the authors to define this tumor as a renal carcinosarcoma. Histogenesis of this tumor and differential diagnosis with other malignant renal tumors are discussed.
Adult↗
[Pathomorphology of adenohypophysis in cases of massive obstetric hemorrhages (morphometric and immunohistochemical studies)].
There have been performed morphometric and immunohistochemical examinations of adenohypophysis of 15 females who died of massive post-partum hemorrhages. The revealed changes in the form of hypertrophy of the basophilic cells are the initial stages of Sheehan's syndrome developing as a result of long-term progression of hypopituitarism. Massive obstetric bleeding causes severe complications-posthemorrhagic shock, the pathogenetic mechanism of which includes necrosis of the cells in the anterior part of the hypophysis. Cause-effect relations were shown for the amount of the post-partum blood loss and the revealed pathomorphologic changes in the hypophysis. Hyperproduction of ACTH by the basophilic cells of the adenohypophysis revealed by immunohistochemical analysis is a compensatory mechanism under the conditions of acute adrenal insufficiency inherent in any shock including posthemorrhagic.
Adrenocorticotropic Hormone↗
[Electron-microscopic study of the lymph nodes and brain of children with a clinical diagnosis of HIV-infection].
Ultrastructural changes in lymph nodes and brain of 7 children with AIDS who died in 1991-1993 in the city of Rostov-on-Don and the Rostov Region have been studied. The results obtained indicated only one case with ultrastructural signs characteristic of AIDS: virus particles with relevant morphology, tubular ring-shaped structures in the cytoplasm. The results of the study compared with the statistic data enable the authors to suggest overstated diagnosis of this disease among children in the Rostov Region.
Acquired Immunodeficiency Syndrome↗
[A morphometric study of the ultrastructure of the axosomatic synapses in the sensorimotor cortex of rats administered the delta-sleep inducing peptide].
Qualitative estimation and quantitative morphometry of ultrastructural changes in layers III, IV, and V in rat sensomotorial cortex after delta-sleep-inducing peptide administration, provides an evidence of multiplication of active inhibitory synapses induced by DSIP. The newly activated synapses may form an axo-somatic synaptic pool participating in optimization of the balance of excitement and inhibition processes in sensomotorial cortex.
Animals↗
[Ratio of neuromediator amino acids in a comparative analysis of the stress protective effects of delta-sleep inducing peptide and piracetam].
The GABAergic system was adequate altered after simultaneous use of delta-sleeping peptide and piracetam in intact animals: gamma-butyric acid was accumulated unidirectionally by inhibiting brain glutamate decarboxylase activity. Administration of the peptide caused a slight decrease in the levels of aspartic acid, while piracetam contributed to a marked accumulation of the amino acid. The antistressor and adaptive effects of each drug were augmented if they were given simultaneously before acute emotional stress developed in the animals during one-hour hypokinesia; these effects were expressed as stabilized balance of inhibitory and excitatory neurotransmitter amino acids.
Adaptation, Physiological↗
[The delta sleep-inducing peptide as a modulator of synaptic ultrastructure].
Results of morphometric study of ultrastructure of axosomatic and axospinous synapses of rat sensomotor neocortex after DSIP administration and in hypoxia showed that the peptide administration resulted in multidirectional changes in these type contacts in intact animals. This, apparently, is connected with their different functional specialization. Preliminary DSIP administration prevented changes, appearing in hypoxia in most of the parameters studied both in axosomatic and axospinous synapses.
Animals↗