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Biomedical subjects

A E New

Publications and source records attributed to A E New.

16 recordsLinked to original sources
PubMed1981

Clinical manifestations of mousepox in an experimental animal holding room.

A study of the clinical aspects of mousepox was conducted during the 1979-80 outbreak at the National Institutes of Health. The disease was detected serologically in a room located adjacent to the index room. The index room received animals prior to this outbreak from a noncommercial colony which later was found to be infected with mousepox. The infection was present in the room for at least 6 weeks prior to the completion of the study. The paucity of clinical signs and low mortality were striking when compared to previous descriptions of mousepox in the United States. Only 27 of the 939 mice in the room were infected, and only one of these had typical skin lesions. A few of the mice had non-specific signs such as ruffled hair coat and hunched appearance. Minimal spread of the disease was evidenced by clustering of infected cages on one of five animal racks in the room.

Animals↗
PubMed1981

Prevention and control of mousepox.

The prevention and control of mousepox begins with investigators being aware of the disease's existence and its serious nature for users of mice and mouse tissues. Every institution must include as part of its management policy, provisions to ascertain that mice and mouse tissues entering its facilities are free of ectromelia virus. Policy must encompass the entire institution, be clearly stated, and must be workable. The provisions of this policy include the establishment of a disease surveillance program which actively searches for disease or virus in incoming mice and mouse tissues from untested sources. Complete records of receipts of animals and animal tissues must be maintained. There must be open and honest communication among investigators concerning the presence of mousepox (and other diseases) in their mice and tumors. Decisions must be based on accurate information. The elimination of mousepox within an institution may be difficult, and a single plan applicable to all situations cannot be given. However, the basics of all control measures include the following: recognition that mousepox represents an institutional problem, not the problem of only a single or a few investigators; rapid notification of all investigators involved, including those who may have received infected mice; confirmation of the diagnosis and notification of the scientific community of the disease's existence. Strategies for dealing with mousepox depend on the nature of the mice infected. Euthanasia of mice which can be replaced and vaccination of extremely valuable breeding stock are suggested.

Animals↗
PubMed1979

A spontaneous outbreak of polychlorinated biphenyl (PCB) toxicity in rhesus monkeys (Macaca mulatta): clinical observations.

A spontaneous, progressive disease occurred in a large domestic breeding colony of rhesus monkeys (Macaca mulatta). The disease was characterized by slow but continuous weight loss, alopecia, acne, facial edema, diarrhea and trauma from other monkeys. Breeding efficiency was impaired with a high incidence of abortions and stillbirths. Live offspring were small and unthrifty contributing to a high infant mortality rate. The cause of this disease was polychlorinated biphenyls (PCSs) which were present in the concrete sealant on the cage floors. Removing the sealant and resurfacing the floors alleviated the problem.

Aggression↗
PubMed1977

A surveillance of human influenza virus in swine in southern Taiwan.

From September 1970 to December 1971, samples were taken monthly from farm pigs, piglets and abattoir pigs in Southern Taiwan for virus isolations and serologic studies. A total of 10 strains of hemagglutinating agent were isolated in January and July 1971, following 2 epidemics of human influenza occurring in December 1970 and June 1971, respectively. Three strains were antigenically confirmed as influenza A similar to A/Hong Kong/68 virus.

Animals↗
PubMed1976

Influenza virus isolations from dogs during a human epidemic in Taiwan.

During an islandwide outbreak of human influenza in June and July 1971, throat swabs were taken from dogs and cats in 3 urban communities of Taiwan. Eight influenza isolates were obtained from dogs in July 1971: two were identified as influenza A closely related to the human Hong Kong/68 virus, and one was a strain of influenza type B closely resembling human influenza B virus. The latter is the first such reported isolation from dogs under natural conditions.

Animals↗