[Cellular mechanisms of increased vascular tonus and reactivity in arterial hypertension].
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Action Potentials↗
Biomedical subjects
A E Rozenberg
Publications and source records attributed to A E Rozenberg.
[Method for collecting rat thrombocytes and determining their aggregation].
Three different methods of blood collection from rats are studied and compared, namely decapitation, catheterization of the carotid artery and puncture of the heart left ventricle. The latter method is preferable in studies of platelet aggregation. The method for isolation of washed platelets from rat blood is described in detail. The platelets stored for several hours at 20 degrees C did not lose the ability for aggregating under exposure to low concentrations of ADP. The curves of aggregation of washed and plasma platelets are provided. To study the rate of aggregation, a model is offered based on the approximation of the aggregation curves by the exponential A = A0exp (-alpha t). Such an approach made it possible to treat the data objectively and to reveal the features of platelet functional activity, particularly in arterial hypertension.
Animals↗
[Calcium sensitivity and aggregative capacity of thrombocytes in rats with spontaneous hypertension at rest and under stress].
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Adenosine Diphosphate↗
[Platelet membranes and thrombocyte aggregation in rats with spontaneous hypertension].
Calcium binding was significantly reduced, and lipid microviscosity increased, in platelet membranes and erythrocyte shadows of spontaneously hypertensive rats (SHR). Their platelet sensitivity to calcium was already increased at the prehypertensive stage, and the rate of A23187-induced platelet aggregation was increased significantly by 24 weeks of life. The demonstrated biochemical properties of SHR's platelet membranes can account for their increased aggregative capacity and may be important in the pathogenesis of arterial hypertension.
Animals↗
[Intracellular La3+-resistant calcium pools in the blood vessels and hearts of rats with spontaneous hypertension].
A significant increase was demonstrated in the capacity of intracellular La3+-resistant calcium pools with high affinity to calcium in the aorta, tail artery and left ventricle of spontaneously hypertensive rats (SHR), while low-affinity pools were only increased in SHR vessels. Rates of 45Ca metabolism in low- and high-affinity pools were significantly higher in SHR aortas as compared to the controls. Increased levels of intracellular metabolizing calcium and its abnormal vascular and heart transport in SHR can account for enhanced reactivity of these tissues and increased peripheral vascular resistance in arterial hypertension.
Animals↗
[Metabolism of Ca-45 in the blood vessels and heart of rats with spontaneous hypertension].
The uptake of 45Ca was increased in the hypertrophic left ventricle of the heart of young (6-7 week) spontaneously hypertensive rats (SHR) at the prehypertensive stage, while at the stage of persistent hypertension (24-26-week SHR), the 45Ca uptake was only increased in the aorta and tail artery. The rates of 45Ca elimination from the vessels of mature SHR proved to be considerably elevated, and those of young SHR unchanged, as compared to the control animals. The findings obtained point to a close association between disorders in vascular and cardiac 45Ca metabolism and the development of hypertension in SHR.
Animals↗
[Binding of 3H-serotonin, 3H-diazepam and lipid peroxidation in brain membranes].
It was demonstrated that the processes of lipid peroxidation in brain tissues of rats induced by hyperoxia and Fe-ascorbate system in vivo and in vitro significantly influence specific binding of serotonin and diazepam. Lipid peroxidation caused various changes in the ability to bind utilized ligands: 3H-serotonin binding decreased by 53%, while that of 3H-diazepam increased by 30%. Preliminary administration of the synthetic antioxidant 4-methyl-2,6-ditretbutylphenol prevented these changes.
Animals↗