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Biomedical subjects

A E Sakharova

Publications and source records attributed to A E Sakharova.

9 recordsLinked to original sources
PubMed1992

[Tactics in using antibiotics in diffuse forms of chronic nonspecific pneumonia in children].

The authors provide the results obtained during many years of studying different aspects of antibacterial treatment of purulent endobronchitis in children with prevalent forms of chronic pneumonia. The study was attempted at the clinic for disease of childhood, I.M. Sechenov Moscow Medical Academy. Base the complex program of such treatment, which rests on etiotropic , correspondence of the antibiotic administration to the activity of the infectious inflammatory process in the bronchi, and immunomodulating therapy carried out according to indications if any. Introduction of the antibiotic therapy program into clinical practice allowed the attainment of good direct results in 87.6% of patients and of stabilization of endobronchitis in 47% of patients within 1.5 to 3 years.

Administration, Oral↗
PubMed1986

[Rapid diagnosis of exacerbations of chronic bronchitis of pneumococcal etiology in children].

The diagnostic possibilities of the microscopic examination of bronchial secretion smears, stained by Gram's method, from 56 children with chronic bronchitis at different stages of exacerbation have been studied. The following criteria have been proposed for confirming the etiological role of pneumococci in cases of endobronchitis in children: the number of paired diplococci in the visual field must exceed 10 with polynuclears covering the whole field. In 84% of cases the use of this method makes it possible to determine the pneumococcal etiology of the disease within two hours from the arrival of the pathological material to a bacteriological laboratory; this method can also be used for evaluating the effectiveness of antibacterial therapy at its different stages.

Bacteriological Techniques↗
PubMed1981

[Gentamicin concentration in the blood and lung tissue of children with bronchopulmonary pathology].

The gentamicin levels in the lung tissue and blood serum of children operated on for bronchiectasis, destructive pneumonia and pleural tumors were studied. The antibiotic was administered intramuscularly in a dose of 3 mg/kg before the operation. The results showed that intramuscular injections of gentamicin provided the antibiotic levels in the lung tissue sufficient for the growth inhibition of the majority of the microbes isolated from such patients. In the patients with congenital developmental defects of the lungs, the level of the antibiotic in the lung tissue 1 hour after its administration was lower than the therapeutic one, while its blood serum levels were high. By the 2nd hour the gentamicin levels in the lung tissue reached those in the patients with acquired bronchopulmonary disease.

Absorption↗
PubMed1978

[Use of the indirect hemagglutination reaction for detecting antibodies to Pseudomonas pyocyanea in acute suppurative destructive pneumonia].

No less than 4-fold increase in the antibody titres to Pseudomonas aeruginosa during the infectious process served as laboratory confirmation of its participation in the infectious process. In 49 of 91 patients hemagglutining titre exceeded the diagnostic one (1:640). In 9 patients (chiefly in infants) hemagglutinin titre remained low, but there was a rise of antibody level to Pseudomonas aeruginosa during the disease. High hemagglutinin titres were noted in 12 patients on admission to the clinic, with reduction of the antibody titres at the late periods of the disease. Antibody titres remained unchanged during the disease in 15 patients. In 3 cases the indirect hemagglutination test was assesed as negative. In the rest of the patients hemagglutinin titres varied within the range of the diagnostic titre. Thus, the indirect hemagglutination test with erythrocytic diagnostic agent permitting to determine antibodies to Pseudomonas aeruginosa could be used at the clinic in combination with bacteriological and other investigations for establishing etiology of the destructive process.

Acute Disease↗