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Biomedical subjects

A E Walts

Publications and source records attributed to A E Walts.

48 records · Page 3Linked to original sources
PubMed1982

Ruptured atheromatous plaques in saphenous vein coronary artery bypass grafts: a mechanism of acute, thrombotic, late graft occlusion.

Although early occlusion of saphenous vein coronary artery bypass grafts is usually thrombotic, late occlusion is most often a result of progressive intimal fibromuscular proliferation or atheroma formation in the implanted vain. We describe another mechanism of late graft occlusion: atheromatous plaque rupture with superimposed occlusive thrombosis. Four men, ages 48-67 years underwent repeat bypass surgery for recurrent angina. Six of eight vein grafts excised 5-8 years after original bypass showed complete luminal occlusion by recent thrombus superimposed on ruptured atheromatous plaques. Similar findings were present at autopsy in two of three vein grafts from a 66-year-old man who died 7 years after bypass. These lesions are indistinguishable from those that occur in native coronary arteries of many patients with acute myocardial infarction. Unlike previously described graft occlusions, the present lesion represents a mechanism of acute, thrombotic, late graft occlusion. If recognized early, it may be amenable to nonsurgical intervention by angioplasty or thrombolysis.

Acute Disease↗
PubMed1980

Intraparotid haemangioma in an adult: case report and review of the literature.

Capillary haemangiomas are among the common benign tumours of the parotid during infancy and childhood. Cavernous haemangiomas are rare lesions in the adult parotid. A cavernous haemangioma of the parotid is described in a 63-year-old woman. The literature is reviewed and the adult and childhood haemangiomas of the parotid are compared.

Adenoma, Pleomorphic↗
PubMed1977

Squamous metaplasia and invasive epidermoid carcinoma of bladder.

Invasive epidermoid carcinoma of the urinary bladder is described in a young woman with a long history of bladder infections and extensive squamous metaplasia without atypia. The literature on squamous metaplasia and leukoplakia progressing to epidermoid carcinoma of the chronic dysuria, bladder infections, and long histories of squamous metaplasia of the bladder should be followed up very closely. If epidermoid carcinoma of the bladder develops, they should undergo radical surgery.

Adult↗
PubMed1977

Benign chondrolipomatous tumor of the human female breast.

A benign chondrolipomatous breast tumor occurred in a 66-year-old woman. The preoperative diagnosis, based on mammography and xeroradiography, was fibroadenoma. Grossly, the demarcated lesion resembled a fibroadenoma with islands of cartilage projecting from its cut surface. Histologically, it was composed of benign mature fibrous stroma, fat, breast ducts, and islands of mature cartilage. Most cartilage-containing tumors of the human breast are associated with primary mammary malignant neoplasms. A few of the benign cartilage-containing tumors reported in the literature are discussed. The last case was published in 1909.

Adenofibroma↗
PubMed1976

Lipomatous lesions of the parotid area.

Lipoma of the parotid gland is a rare lesion in adults and children, and appears most frequently in the fifth and sixth decades of life. Thirty-two lipomatous lesions of the parotid gland and periparotid area are reviewed. One lipoma occurred in a 7-year-old boy. The lesion shows a definite sex preference, with a male to female ratio of 10:1. The lesion shows no laterality preference. The most frequent preoperative diagnoses in our series were mixed tumor and Warthin tumor. In general, these lesions are soft, mobile, and painless and enlarge slowly. They are not associated with neurological deficits, skin changes, other salivary gland lesions, or with lipomas elsewhere in the body. The surgical management of this lesion should be the same as for any other parotid tumor with due regard for the presence of the facial nerve in the operative field. There were no facial nerve injuries in this series. If totally excised, these lesions show no tendency to recur.

Adult↗
PubMedDate not supplied

Malignant melanoma in effusions: a source of false-negative cytodiagnoses.

Melanoma, a not uncommon tumor, is associated with variable cytomorphology and unpredictable metastatic potential. Although most cytologic diagnoses of malignant melanoma represent metastatic disease, the diagnosis is frequently unsuspected clinically. Three effusions in which cells from metastatic melanomas were not diagnosed are described. Clinical factors that may have contributed to the erroneous cytodiagnoses are illustrated. Cytologic features and adjunctive studies that are helpful in identifying melanoma cells are discussed.

Aged↗
PubMedDate not supplied

Specific tumor markers in diagnostic cytology. Immunoperoxidase studies of carcinoembryonic antigen, lysozyme and other tissue antigens in effusions, washes and aspirates.

The immunoperoxidase technique was used to identify specific tumor markers in exfoliated cells in fine needle aspirates and body fluids. Carcinoembryonic antigen (CEA) and lysozyme staining was evaluated in cytocentrifuge preparations from 42 malignant effusions and aspirates and 16 benign effusions. Reactive mesothelial cells were negative for CEA and lysozyme or showed faint peripheral cytoplasmic staining. Malignant cells from 50% of the adenocarcinomas studied were positive for CEA. All tumors studied were negative for lysozyme. These staining patterns are helpful in the differential diagnosis of reactive mesothelial and adenocarcinoma cells, a frequent diagnostic dilemma. Moreover, demonstration of specific tumor antigens (e.g., prostatic acid phosphatase, calcitonin and immunoglobulin) helped define the origin of metastatic malignancy in selected cases. Estrogen receptor activity was also identified in tumor cells using this technique. Immunoperoxidase was helpful in the evaluation of malignant cytologic specimens from patients with more than one tumor. Interpretation of staining patterns is discussed, with reference to the limitations of the technique. Immunoperoxidase methods maintain cytologic detail, are readily adaptable to diagnostic cytology and increase the specificity of cytologic diagnosis.

Acid Phosphatase↗
PubMedDate not supplied

Osteoclast-type giant-cell tumor of the pancreas.

The incidence of pancreatic malignancies in Western countries is increasing. Acceptance of fine needle aspiration as a diagnostic tool in the evaluation of pancreatic lesions necessitates that cytologists recognize unusual tumor variants as well as adenocarcinoma. The aspiration cytology of a pancreatic carcinoma containing osteoclast-type giant cells is reported, and the differential diagnosis of multinucleated giant cells in pancreatic aspirates is discussed.

Biopsy, Needle↗