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Biomedical subjects

A Ebert

Publications and source records attributed to A Ebert.

At least 55 records · Page 3Linked to original sources
PubMed1993

[Adolf Gusserow (1836-1906), founding of the 2d University Gynecologic Clinic of the Charité and the Berlin Society of Obstetrics and Gynecology. IV].

Adolf Gusserow was one of the outstanding German gynecologists at the end of the XIX. century. Although interested in the entire discipline of obstetrics and gynecology including related areas, he is merely unknown today. This paper describes the biography of Prof. A. Gusserow, but also his importance for the Berlin Society of Obstetrics and Gynecology.

Berlin↗
PubMed1992

[Use of xylocaine in placing afterloading applicators in the gynecologic area--a simplified and analgesic method].

The afterloading contact therapy is an established method in the therapy strategies of extended gynecological malignancies. Unfortunately, the manipulations of application are painful in many cases. The results of the present paper suggests, that the pretherapeutic application of Lidocain (Xylocain) may decrease in pain symptomatic significantly. This findings have relevance for ambulant afterloading contact therapy.

Anesthesia, Local↗
PubMed1992

[Pregnancy after successful therapy of HBV-associated hepatocellular cancer--a case report].

Malignant tumors are a difficult problem in obstetrics, both in pregnancy but also after an successful therapy, especially, if the patient wishes to be pregnant. However, there are borderline cases of medical and ethical regions. In the present paper the case of a young women (21 years old) with HCC is described. In the age of 16 years a solid hepatocellular carcinoma was found and treated by partial resection of the right lobus hepaticus. Anamnestically a blood exchange transfusion caused by a neonatal Rh-incompatibility and a hepatitis B in the age of 11 months are known. 3 and 6 years after the treatment, she was successfully pregnant and is today mother of 2 children.

Adult↗
PubMed1992

[C-1 esterase inhibitor deficiency as an obstetric problem: a case report].

The present paper reports a case of C-1-esterase-inhibitor-deficiency in pregnancy. After preoperative i.v. application of 500 E-1-esterase the section caesarean was performed. Problems of this disease, relevant for obstetrics have been described. An interdisciplinary cooperation between obstetrics, anaesthetics and dermatologists is important.

Adult↗
PubMed1992

[The protocol book I. An important contribution to the history of the German Cancer Society (1900-1907)].

On initiative of E. von Leyden the committee for cancer research, the origin of the present German Cancer Society was founded in Berlin in 1900. In 1991 in the Charité the original minute book of the committee of the years 1900 to 1907 was found. This historical document gives interesting insight into the beginnings of the German combat against cancer, themes treated, organisational questions and particulars of persons.

Cancer Care Facilities↗
PubMed1992

[Eduard Arnold Martin (1809-1875)--founder of the Berlin Gynecologic Society. A contribution to the history of the Berlin Society of Obstetrics and Gynecology. II].

In 1844 the society of obstetrics in Berlin was founded by Carl Mayer (1795-1868). In 1873 this society splits in the society of obstetrics and the society of gynaecology. The present paper demonstrate the biography of Eduard Arnold Martin (1809-1875), the founder of the gynaecological society in Berlin (1873) and also his importance in the creation of an modern gynaecology.

Berlin↗
PubMed1992

[115 years Berlin Society of Obstetrics and Gynecology: Carl Ludwig Ernst Schröder, progress and effect. Part III].

115 years age (1876) in Berlin the Society of obstetrics and gynaecology was founded by fusion of the society of obstetrics (1844) and the society of gynaecology (1873). As first president was elected Carl Schröder, the new ordinarius of the Gynaecological Department (Universitäts-Frauenklinik). The present paper descirpt the live and work of Carl Schröder on the background of Berlin Gynaecology in last decades of the XIX. century.

Berlin↗
PubMed1991

[Improvement in nuclear medicine diagnosis of kidney function using 99m technetium mercaptoacetyltriglycine (MAG3)].

Renal scintigraphy and clearance measurement are indispensable in nephro-urologic disorders. A continuous series of 103 sequential scintigraphies and clearance measurements were performed with the new technetium-labelled agent MAG3 (Gamma-kamera, Phillips Tomo Diagnost) and 131I-orthohippuric acid (OIH) using the Oberhausen method (Nucleopan, Siemens). The time-activity curves obtained with the two radionuclides agreed exactly. Reaching a tubular excretion rate of nearly 90%, the clearance of MAG3 differed by no more than 6% from the OIH clearance in 95% of the cases. The factor between clearances of the two radionuclides was determined by means of a commercially available software according to the Oberhausen method and amounted to 0.59 +/- 0.09. The favorable physical properties and high activity of MAG3 permit exact examination of tubular function and better assessment of renal morphology than hippuran-labelled radionuclides. The low radiation dose combined with a better spatial resolution, especially, the constant availability in a nuclear medicine department should give the preference to MAG3.

Adult↗
PubMed1991

[Carl Wilhelm Mayer (1795-1868)--founder of the Berlin Society of Obstetrics].

115 years ago the society of gynaecology and obstetrics in Berlin was found. Already in 1844 the Berlin physician and obstetrician Carl Wilhelm Mayer (1795-1868) has initiated the foundation of a society of obstetrics. This was the first medical-scientific society of the world. We want to demonstrate the biography of C. W. Mayer and also his importance in the creation of a modern medical association. In the second part of present paper, the situation of foundation and the first years of the Berlin society of obstetrics were described.

Berlin↗
PubMed1989

[Are there regional differences in Tc uptake?].

The 99mTcO4-uptake (TcTU) was measured in 363 clinically and by laboratory findings euthyroid patients without history of hyper- or hypothyroidism, no evidence of iodine contamination and with a Delta-TSH less than 2.5 IU under a longterm suppressive thyroxine therapy. The medians of TcTU in the different regional groups from the Federal Republic of Germany (mail zip code 2000-8000) were not statistically different from each other, indicating that under suppression with thyroxine the effect of the iodine supply on TcTU is nearly negligible, and that, using the same method, results from different nuclear medicine departments should not differ significantly from each other.

Adult↗
PubMed1989

[Results of antineoplastic chemotherapy based on the oncobiogram].

An organ culture assay for in vitro chemosensitivity testing was used to predict clinical responses of various tumors to antineoplastic chemotherapy. 9 patients with advanced mammary carcinomas, 7 patients with metastatic malignant melanomas, 1 patient with advanced ovarian cancer, 1 with bronchogenic carcinoma, 1 with metastatic leiomyosarcoma and 1 patient with a metastatic carcinoma of the sweat gland were included in the study. 20 in vitro-in vivo correlations were evaluable. 5/9 of the mammary carcinomas showed an objective response, 0/7 malignant melanomas were sensitive in vivo. Further investigations have to assess the value of chemosensitivity assays to predict clinical response for patients with solid tumors.

Antineoplastic Agents↗
PubMed1989

[30 January 1878: Wilhelm Alexander Freund and the abdominal extirpation of the uterus].

At the 30 January 1878 the gynaecologist Wilhelm Alexander Freund (University of Breslau) succeeded in performing the first exstirpation of an uterus with cervical carcinoma by his abdominal method. By this way a new chapter of surgical gynaecology was opened. The purpose of this article is to remember the jewish physician and scientist whose work gave the impetus for fundamental changes of the therapy of malignant uterus at the end of the XIX. century.

Female↗
PubMed1988

Heterogeneous expression of glutamine synthetase mRNA in rat liver parenchyma revealed by in situ hybridization and Northern blot analysis of RNA from periportal and perivenous hepatocytes.

Using radiolabeled specific cDNA glutamine synthetase mRNA could be detected by in situ hybridization exclusively within those few perivenous hepatocytes which stained immunocytochemically for glutamine synthetase. This localization of glutamine synthetase mRNA was recently reported by Moorman et al. [(1988) J. Histochem. Cytochem. 36, 751-755]. Biotinylated cDNA was not suitable for mRNA detection because of a very high background staining under the conditions of in situ hybridization. Dot blot and Northern blot analysis of RNA isolated from periportal and perivenous subfractions of hepatocytes also demonstrated the exclusive perivenous localization of two hybridizable glutamine synthetase mRNAs of length 2.8 and 1.6 kilobases. These results indicate that the unique heterogeneity of glutamine synthetase in rat liver parenchyma is controlled at the pretranslational level.

Animals↗
PubMed1988

[Quantitative histological studies of lamina V and lamina III pyramidal neurons in the motor cortex of the rat. The question of laterality].

Laterality of several brain functions has been demonstrated in the human brain cortex as well as in several animal species indicating an evolutionary genesis of the brain's asymmetry. To get some morphological data, we investigated Golgi impregnated pyramidal neurons in lamina III of regio precentralis agranularis of the major cortex from adult rats. The spine number and density and the length of the dendrites forming a basal or apical single dendritic field (SDF = EDF) of these neurons were estimated. The statistical significance of the data was proved by comparing the neuronal parameters obtained from the right or left hemisphere of the same animal (individual laterality), as well as by testing the mean values from right or left cortex of several animals (species laterality). However, in both cases no statistical significance could be obtained. From these results two conclusions should be drawn: Firstly, the parameters in a single dendritic field of cortical pyramidal neurons of both brain sides are statistically equivalent and not asymmetrical developed. Secondly, the single dendritic field of cortical pyramidal neurons can not serve as a morphological counterpart for functional asymmetries in the rat brain. Here, further interdisciplinary research is necessary.

Animals↗
PubMed1987

Gene cluster for streptomycin biosynthesis in Streptomyces griseus: nucleotide sequence of three genes and analysis of transcriptional activity.

Three streptomycin (SM) production genes from Streptomyces griseus clustered around aphD, the major resistance gene, have been sequenced: strB, coding for an aminocyclitol amidinotransferase, ORF5 (strR), a putative regulatory gene, and ORF1 (strD), possibly coding for a hexose nucleotidylating enzyme. Three promoters and at least five, partially overlapping, transcripts have been identified by S1 mapping and Northern blot experiments. aphD, the resistance gene, is transcribed from two promoters. One of them, located inside the strR gene, seems to be constitutive and the other is switched on later in the growth phase. The late transcripts cover the resistance gene (aphD) and a regulatory gene (strR) which controls the expression of strB.

Amino Acid Sequence↗
PubMed1987

Gene cluster for streptomycin biosynthesis in Streptomyces griseus: analysis of a central region including the major resistance gene.

A central segment of a cluster of biosynthetic genes for the antibiotic streptomycin cloned from Streptomyces griseus was analysed for open reading frames, as well as for transcriptional and translational activity. The nucleotide sequence revealed two significant open reading frames, ORF1 and APH(6), orientated in opposite directions and with a spacer of 885 bp between the start codons. The first, ORF1, had a coding capacity of 38 kDa. One open reading frame, APH(6), was identified as the major resistance gene coding for streptomycin 6-phosphotransferase, a protein of 307 amino acid residues and 33 kDa. Sequence determination of the first 14 N-terminal amino acid residues of the purified APH(6) enzyme protein was in agreement with the proposed primary structure. The possible identity of the presumed gene product of ORF1 with an in vitro translated protein (apparent molecular weight 41 kDa) is discussed. Comparison of the two APH(6) genes from S. griseus and the hydroxystreptomycin-producing S. glaucescens (cf. Vögtli and Hütter 1987) revealed 75% nucleotide sequence homology in the coding region and 74% conservation of the polypeptide sequence. Two protein domains which are highly conserved in other antibiotic and protein phosphotransferases were detected.

Amino Acid Sequence↗
PubMed1977

Advantages of potassium cardioplegia and perfusion hypothermia in left ventricular hypertrophy.

An attempt was made to determine the effect of hypothermic potassium cardioplegia (35 mEq of potassium chloride) on the hypertrophic ventricle. Puppies with induced left ventricular hypertrophy were divided into four groups and studied after one hour on global ischemia. Myocardial adenosine triphosphate (ATP) was best preserved in the hypothermically perfused groups and correlated well with measurements of coronary sinus creatine phosphokinase (CPK). In Groups 1 and 2 (anoxic arrest at 37 degrees C and KC1 perfusion at 37 degrees C), CPK at 30 minutes of reperfusion was 1,031 and 198 IU, respectively, compared to 35 IU in Group 3 (KC1 perfusion at 4 degrees C) and 44 IU in Group 4 (Ringer's lactate at 4 degrees C). Myocardial injury was milder in Groups 3 and 4 regardless of whether potassium chloride was added. It is apparent that hypothermic perfusion of a hypertrophic ventricle was the major factor in myocardial preservation, as determined by myocardial ATP and coronary sinus CPK.

Adenosine Triphosphate↗