PubMed Health⌕ Search

Biomedical subjects

A Echavarría

Publications and source records attributed to A Echavarría.

5 recordsLinked to original sources
PubMed1998

A study of granulocyte respiratory burst in patients with allergic bronchial asthma.

The respiratory burst of phagocytes plays an important role in the tissue damage that accompanies the inflammatory response. One of these conditions is allergic bronchial asthma, therefore, to evaluate the activation state of peripheral granulocytes the generation of reactive oxygen metabolites was evaluated using Luminol-enhanced chemiluminescence (LCL) and reduction of cytochrome C by superoxide. The resting granulocytes of the asthmatic patients under crisis showed a higher LCL compared to the noncrisis patients and control subjects. The granulocytes stimulated with PMA presented a significant increase in the respiratory burst in both groups of asthmatics. The granulocytes of noncrisis asthmatics challenged with Ops-Zym and with fMLP + Ops-Zym showed a higher metabolic activity, whereas the asthmatics under crisis presented no difference between reactive oxygen generation and that of the control group. The quantitative analysis of superoxide generation by granulocytes of the same patients did not show differences among the groups. Our findings suggest that the granulocytes of crisis and noncrisis asthmatics seem to be in a hyperreactive state and with a higher metabolic response when compared to the control group. However, the patients present a different behavior depending on stimulus used to activate cells. This could indicate that in peripheral blood exist different granulocyte populations depending on the inflammatory response taking place in the respiratory tract.

Adult↗
PubMed1991

[Pulmonary cryptococcosis].

The authors present the clinical history of a 61 year old woman who was treated in the Metropolitan Hospital Complex Arnulfo Arias Madrid of the Social Security. The patient had experienced weight loss, chills and pain in the left chest for a period of one month. The chest X-ray showed an irregular oval shaped pulmonary infiltrate, 5 x 5 cm, in the upper one third of the left lung field. Fiberoptic bronchoscopy revealed an endobronchial lesion in the superior division of the left upper lobe bronchus. Transbronchial biopsy and bronchial brushings showed Crytpcoccus neoformans. Clinical evaluations did not reveal involvement of the central nervous system, the immunological system or evidence of neoplastic disease. The patient was treated with Amphotericin B and Ketoconazole resulting in a complete cure. Amphotericin B was used on an ambulatory basis for the first time in their institution and in Panama.

Cryptococcosis↗
PubMed1991

[Intracavitary treatment of malignant pleural effusion with iodine-povidone].

The authors present 15 patients with proven malignant pleural effusion who underwent pleurodesis with Povidone. They obtained a complete response in 100% of the cases. The average duration of the response was 23.3 weeks ranging from 3 to 83 weeks. Seven patients are alive and on follow up with an average response time of 30 weeks. Six patients are dead, with an average response time of fifteen weeks. We don't know the late results in 2 patients after the control (4 weeks after treatment). The pleural tube remained in place from 2 to 8 days. There were no untoward or colateral effects in these patients. The cost of the Povidone utilized was B/0.40 per patient. The cost, the efficacy and the absence of ill effects make Povidone the agent of choice in the palliative treatment of malignant pleural effusion.

Brachytherapy↗
PubMed1990

[Diffuse malignant mesothelioma. Presentation of 10 cases and review of the literature].

The authors study ten cases of malignant diffuse mesothelioma diagnosed histologically in the CH-Dr-AAM-CSS. Of the ten cases eight were men and two women, from 22 to 73 years of age. No evidence of exposure to asbestos was elicited by the nature of their occupation or their place of residence. The clinical findings in all cases is similar to those found in this type of disease. The radiologic findings were limited: pleural effusion, pulmonary fibrosis, and pulmonary mass. To make a definitive diagnosis it was necessary to use an invasive procedure. Examination of sputum, bronchial washings and endobronchial biopsies did not contribute to the diagnosis. The cytological examination of pleural and ascitic fluid resulted in a diagnosis of malignancy. In four cases the diagnosis was made by closed pleural biopsy; in five other cases it was necessary to obtain specimens by thoracotomy. In the last case the diagnosis was made at autopsy. The authors reviewed the original slides and additional slides from the paraffin blocks of the biopsies and of the autopsy. The diagnoses made by the pathologists were listed according to the classification of the AFIP (1).

Adult↗