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A Egre

Publications and source records attributed to A Egre.

29 records · Page 2Linked to original sources
PubMed1975

[Respective value of labelled fibrinogen and rheography in the detection of phlebitis].

The authors have studied in 212 patients the diagnostic value of radio-active fibrinogen and rheography in deep venous thrombosis of the leg by comparing the results from these two methods with phlebography. Radio-active fibrinogen seems the better means of diagnosis in early distal phlebitis. However, the method is expansive, the radio-active substance can only be manipulated in certain specialized centers, and is useless in the presence of hematoma. Rheography is less expansive, more easily manipulated, yet less sensitive as only proximal phlebitis can be detected-especially when completely occlusive. In addition, active patient cooperation is necessary. The time needed to realize the two methods is a major obstacle; however, they can be fruitful if integrated into a specialized department for the diagnosis and treatment of thrombo embolic disease.

Collateral Circulation↗
PubMedDate not supplied

Mass spectrometric identification of amiodarone N-monodesethyl metabolite and application of an HPLC method to a pharmacokinetic study.

Identification of an amiodarone metabolite in the plasma of patients receiving a single dose of the drug was carried out by mass-spectrometry following extraction and HPLC separation. The kinetics of the plasma concentrations of unchanged compound and its identified metabolite (N-monodesthyl-amiodarone) were studied in six patients after a single administration of amiodarone by oral or intravenous routes, using a sensitive and specific high-performance liquid chromatographic method. The observed plasma clearance rate for the drug varied from 0.2 to 0.5 1.h-1.kg-1 of body weight; and the elimination half-life of the unchanged compound was found to be approximately 21 hours. Oral bioavailability, as determined in one patient, was about 60%. The proportion of the metabolite found in the plasma following a single oral administration was significantly higher than that observed after infusion. The ratio of areas under the curves for metabolite-to-unchanged compound was 0.55 and 0.13 for oral and intravenous doses respectively. During a circumscribed study carried out in five patients receiving oral doses of the drug (daily dose varied from 2.6 to 9.3 mg/kg) accumulation of the metabolite was observed. The mean of the plasma level ratios (metabolite to-unaltered drug) obtained in five patients was approximately 0.97.

Aged↗