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Biomedical subjects

A Ekeland

Publications and source records attributed to A Ekeland.

14 recordsLinked to original sources
PubMed1992

No effects of local somatomedin C on bone repair. Continuous infusion in rats.

We studied the effect of continuous local application of human recombinant somatomedin C (110 micrograms/100 g/day) on bone repair in a rat femoral osteotomy model. The mechanical strength and various metabolic variables were evaluated four weeks postoperatively. We did not find any effect in the treatment group as compared to controls on torsional strength, deformation, or stiffness. Radiographic healing was similar in both groups. Nor was there any difference in callus weight, callus vascularization, or mineralization. Our results suggest that local administration of this dose of somatomedin C does not promote the early phase of diaphyseal repair in long bones.

Animals↗
PubMed1992

Femoral shaft fractures in the elderly treated with Grosse-Kempf slotted locked intramedullary nail.

Thirty-one femoral shaft fractures in patients over 60 years of age were treated with the Grosse-Kempf slotted, locked intramedullary nail and followed for a median of 24 months. The patients tolerated the operation reasonably well and the mortality was not higher than the mortality connected with femoral neck fractures. Three reoperations were performed due to intra- and postoperative complications. The main reason for the less satisfactory result was shortening > 2 cm after unstable dynamical locking. This occurred in 8 of 15 dynamically nailed fractures with locking screw(s) in one end of the nail only. A 9 cm shortening among these was the reason for one of the two poor results in the series. The other poor result was a malalignment of the distal fragment in a statically locked fracture. We conclude that locked intramedullary nailing is a good way to treat femoral shaft fractures in the elderly, the high subtrochanteric, midshaft and infraisthmic fractures.

Aged↗
PubMed1992

Comparison of functional bracing and locked intramedullary nailing in the treatment of displaced tibial shaft fractures.

Thirty-five displaced tibial shaft fractures, treated with functional bracing were compared with 43 similar fractures, treated with locked intramedullary nailing. There were 22 excellent/good results in the brace group and 38 in the nail group. There was one infection in the brace group and three in the nailed group. There were five delayed unions and two nonunions in the brace group and one delayed union in the nail group. The functional results in the nailed group were better than the braced group but locked intramedullary nailing of tibial shaft fractures require special resources and training. Locked intramedullary nailing fullfils all the functional criteria for acceptable fracture care.

Adolescent↗
PubMed1991

Locked intramedullary nailing of femoral shaft fractures.

One hundred twenty-three femoral shaft fractures were treated with Grosse-Kempf slotted, locked nails and followed for a median 20 (range, 12-60) months. There were eight intraoperative and 11 postoperative complications, among them two superficial and two deep infections. Most of the intraoperative complications and some postoperatively lost reductions could have been prevented by a better operative technique and judgment of stability. Seventy-eight results were graded as excellent, 24 as good, 19 as fair, and two as poor (one 9-cm shortening and one 40 degrees external malrotation). All fractures united without further procedures during the first year.

Adolescent↗
PubMed1991

Subtrochanteric femoral fractures treated with locked intramedullary nails. Experience from 31 cases.

We treated 31 proximal femoral shaft fractures, where the trochanteric area was intact, with Grosse-Kempf locked intramedullary nails. There were 19 men and 12 women with a median age of 24 (14-79) years. Sixteen fractures were comminuted and 11 were a component of severe multiple injury. No infections or other serious complications occurred. All the fractures healed within 40 weeks, with 16 results graded as excellent, 7 as good, 7 as fair, and 1 as poor. Six fair results were due to difficulties in aligning the short proximal fragment. One patient with a fair and 1 with a poor result had excessive shortening of the femur. We conclude that locked intramedullary nailing is a good alternative in these fractures and that the static variant is preferable whenever the stability is uncertain.

Adolescent↗
PubMed1990

Locked intramedullary nailing for displaced tibial shaft fractures.

We analysed the results of 93 tibial shaft fractures treated with the Grosse-Kempf locked nail. Twenty-six fractures were comminuted, 19 were open grade I to II, and 54 were located outside the middle third of the tibia. The deep infection rate was 3.2%. There were only two poor results. The use of this method is recommended and discussed.

Adolescent↗
PubMed1990

No effect of systemic administration of somatomedin C on bone repair in rats.

The effect of somatomedin C on the bone repair process was studied in a rat femoral osteotomy. We used continuous systemic administration of human recombinant somatomedin C (110 micrograms/100 g per day). Radiographic evaluation after 4 weeks showed no effect of somatomedin C on the healing. There was no effect on mechanical strength, and no effect was found on callus vascularization or mineralization. The weight of the callus was slightly reduced in the somatomedin C treated rats. The results were not suggestive of any acceleration with systemic somatomedin C treatment in the early phase of cortical bone repair.

Animals↗
PubMed1990

The Grosse-Kempf nail for distal femoral fractures. 2-year follow-up of 25 cases.

Totally, 25 patients with an infraisthmic fracture of the femur, treated with a Grosse-Kempf slotted nail, were followed up for a median of 21 (8-44) months. The median age of the 9 males and 16 females was 45 (18-90) years. No deep infections occurred. An excellent result was obtained in 14 patients, good in 5, fair in 5, and poor in 1 patient in whom intraoperative splintering led to a 9-cm shortening. We conclude that intramedullary locked nailing of fractures of the infraisthmic, extraarticular part of the femur compares favorably with alternative methods.

Adult↗
PubMed1990

[Experiences with interlocking nails in the femur. A retrospective analysis of 99 operated femur shaft fractures].

In 95 patients 99 femoral fractures treated with an intramedullary locking nail were followed-up for median 22 months (12-60). 62 results were classified as excellent, 19 as good and 16 results as fair. A poor result was registered in 2 patients. We had 13 operation-related complications. Four of these complications required a new operation and one ended up with a poor end-result. Operative-technical complications do not necessarily need to impair the result if the surgeon is aware of them and knows how they are to be handled.

Adolescent↗
PubMed1978

Effect of meglumine metrizoate and metrizamide on the microcirculation. Animal experiments.

Physiologic saline, meglumine metrizoate (Isopaque) and metrizamide (Amipaque) were injected into the ear artery of Wedder rabbits. The effect on the microcirculation in previously inserted ear chambers was recorded by cinematography. Following injection of the contrast media, the circulation was slow, followed by a phase with arteriolo-venular shunting and poor capillary circulation.

Animals↗
PubMed1978

Methods for testing the mechanical properties of the rat femur.

A modular apparatus to measure the bending and torsional properties of the rat femur is presented. Both intact femur diaphyses and diaphyseal fractures in different phases of healing can be tested. It is also possible to measure the bending-strength of the distal femur metaphysis and the epiphyseal plate. The apparatus can be used to investigate the effect of drugs and hormones on the remodelling of the rat femur.

Animals↗
PubMed1976

An urodynamic study of emepronium bromide in bladder dysfunction.

The effect of emepronium bromide in 13 patients, most of whom had uninhibited bladders, has been studied urodynamically. Under the influence of this drug, the detrusor pressure and the urinary flow was reduced, and abdominal straining during during micturition was commonly recorded. The bladder capacity increased considerably, but all subjects developed residual urine. The effect of emepronium bromide on the bladder capacity seemed to last for a longer period than the effect on the detrusor pressure.

Child↗